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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Bet1  -  Bet1 golgi vesicular membrane trafficking...

Rattus norvegicus

Synonyms: BET1 homolog, Golgi vesicular membrane-trafficking protein p18, rBET1
 
 
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High impact information on Bet1

  • Bet1p plays an essential role in vesicular transport from the endoplasmic reticulum (ER) to the Golgi in yeast, and it functions as a vesicle soluble N-ethylmaleimide-sensitive factor protein receptor (v-SNARE) [1].
  • After treating surface IgM molecules on B lymphocytes with papain to cleave Fab fragments, the b allotype reactivity of AF6-78.25 mouse Mab, but not 331.12 rat Mab, disappeared, whereas the a allotype reactivities of two rat Mab (Bet-1, 331.12) were not altered [2].
 

Anatomical context of Bet1

  • Bet 1 defines a new allotypic determinant, Igh-6.5, expressed on IgM molecules in serum and on B lymphocytes, whereas Bet 2 recognizes a determinant on IgM molecules of all mouse strains tested [3].
 

Analytical, diagnostic and therapeutic context of Bet1

  • We have used two rat monoclonal antibodies (Mab) (Bet-1 and 331.12), a mouse Mab (AF6-78.25), and an alloantiserum (SJA anti-BAB/14) in two-color immunofluorescence analysis and enzyme-linked immunosorbent assays to examine the expression of IgM allotypes at various stages of mouse B cell development, especially at the pre-B cell stage [2].

References

  1. GS15, a 15-kilodalton Golgi soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) homologous to rbet1. Xu, Y., Wong, S.H., Zhang, T., Subramaniam, V.N., Hong, W. J. Biol. Chem. (1997) [Pubmed]
  2. Analysis of the reactivity of four anti-mouse IgM allotype antibodies with mu+ B lineage cells at various stages of differentiation. Velardi, A., Kubagawa, H., Kearney, J.F. J. Immunol. (1984) [Pubmed]
  3. A mouse IgM allotypic determinant (Igh-6.5) recognized by a monoclonal rat antibody. Kung, J.T., Sharrow, S.O., Sieckmann, D.G., Lieberman, R., Paul, W.E. J. Immunol. (1981) [Pubmed]
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