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Gene Review

PACSIN3  -  protein kinase C and casein kinase...

Homo sapiens

Synonyms: Protein kinase C and casein kinase substrate in neurons protein 3, SDPIII, SH3 domain-containing protein 6511
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High impact information on PACSIN3

  • A similar shift was also observable when we blocked dynamin-mediated endocytotic processes, suggesting that PACSIN 3 specifically affects the endocytosis of TRPV4, thereby modulating the subcellular localization of the ion channel [1].
  • Two of these, Pacsin 3 and Sorting Nexin 9, were confirmed by immunoprecipitation [2].
  • To determine how ADAM12 is activated, we screened proteins that bind to the cytoplasmic domain of ADAM12 using a yeast two-hybrid system and identified a protein called PACSIN3 that contains a Src homology 3 domain [3].
  • The overexpression of PACSIN3 in HT1080 cells enhanced 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced proHB-EGF shedding [3].
  • This defect in the secretory pathway correlates with loss of polyunsaturated fatty acids from cellular lipids, and with the lack of expression of endophilin-I and CtBP/BARS, enzymes that regulate vesicle fission by catalyzing the acylation of arachidonate into lysophosphatidic acid [4].

Associations of PACSIN3 with chemical compounds

  • Furthermore, knockdown of endogenous PACSIN3 by small interfering RNA in HT1080 cells significantly attenuated the shedding of proHB-EGF induced by TPA and angiotensin II [3].

Other interactions of PACSIN3

  • Furthermore, co-immunoprecipitation and co-localization analyses of ADAM12 and PACSIN3 proteins also revealed their interaction in mammalian cells expressing both of them [3].
  • Our data indicate that PACSIN3 has a novel function as an up-regulator in the signaling of proHB-EGF shedding induced by TPA and angiotensin II [3].


  1. PACSINs bind to the TRPV4 cation channel. PACSIN 3 modulates the subcellular localization of TRPV4. Cuajungco, M.P., Grimm, C., Oshima, K., D'hoedt, D., Nilius, B., Mensenkamp, A.R., Bindels, R.J., Plomann, M., Heller, S. J. Biol. Chem. (2006) [Pubmed]
  2. A novel proteomic screen for peptide-protein interactions. Schulze, W.X., Mann, M. J. Biol. Chem. (2004) [Pubmed]
  3. PACSIN3 binds ADAM12/meltrin alpha and up-regulates ectodomain shedding of heparin-binding epidermal growth factor-like growth factor. Mori, S., Tanaka, M., Nanba, D., Nishiwaki, E., Ishiguro, H., Higashiyama, S., Matsuura, N. J. Biol. Chem. (2003) [Pubmed]
  4. Lack of Fas/CD95 surface expression in highly proliferative leukemic cell lines correlates with loss of CtBP/BARS and redirection of the protein toward giant lysosomal structures. Monleón, I., Iturralde, M., Martínez-Lorenzo, M.J., Monteagudo, L., Lasierra, P., Larrad, L., Piñeiro, A., Naval, J., Alava, M.A., Anel, A. Cell Growth Differ. (2002) [Pubmed]
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