The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

PACSIN3  -  protein kinase C and casein kinase...

Homo sapiens

Synonyms: Protein kinase C and casein kinase substrate in neurons protein 3, SDPIII, SH3 domain-containing protein 6511
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

High impact information on PACSIN3

  • A similar shift was also observable when we blocked dynamin-mediated endocytotic processes, suggesting that PACSIN 3 specifically affects the endocytosis of TRPV4, thereby modulating the subcellular localization of the ion channel [1].
  • Two of these, Pacsin 3 and Sorting Nexin 9, were confirmed by immunoprecipitation [2].
  • To determine how ADAM12 is activated, we screened proteins that bind to the cytoplasmic domain of ADAM12 using a yeast two-hybrid system and identified a protein called PACSIN3 that contains a Src homology 3 domain [3].
  • The overexpression of PACSIN3 in HT1080 cells enhanced 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced proHB-EGF shedding [3].
  • This defect in the secretory pathway correlates with loss of polyunsaturated fatty acids from cellular lipids, and with the lack of expression of endophilin-I and CtBP/BARS, enzymes that regulate vesicle fission by catalyzing the acylation of arachidonate into lysophosphatidic acid [4].
 

Associations of PACSIN3 with chemical compounds

  • Furthermore, knockdown of endogenous PACSIN3 by small interfering RNA in HT1080 cells significantly attenuated the shedding of proHB-EGF induced by TPA and angiotensin II [3].
 

Other interactions of PACSIN3

  • Furthermore, co-immunoprecipitation and co-localization analyses of ADAM12 and PACSIN3 proteins also revealed their interaction in mammalian cells expressing both of them [3].
  • Our data indicate that PACSIN3 has a novel function as an up-regulator in the signaling of proHB-EGF shedding induced by TPA and angiotensin II [3].

References

  1. PACSINs bind to the TRPV4 cation channel. PACSIN 3 modulates the subcellular localization of TRPV4. Cuajungco, M.P., Grimm, C., Oshima, K., D'hoedt, D., Nilius, B., Mensenkamp, A.R., Bindels, R.J., Plomann, M., Heller, S. J. Biol. Chem. (2006) [Pubmed]
  2. A novel proteomic screen for peptide-protein interactions. Schulze, W.X., Mann, M. J. Biol. Chem. (2004) [Pubmed]
  3. PACSIN3 binds ADAM12/meltrin alpha and up-regulates ectodomain shedding of heparin-binding epidermal growth factor-like growth factor. Mori, S., Tanaka, M., Nanba, D., Nishiwaki, E., Ishiguro, H., Higashiyama, S., Matsuura, N. J. Biol. Chem. (2003) [Pubmed]
  4. Lack of Fas/CD95 surface expression in highly proliferative leukemic cell lines correlates with loss of CtBP/BARS and redirection of the protein toward giant lysosomal structures. Monleón, I., Iturralde, M., Martínez-Lorenzo, M.J., Monteagudo, L., Lasierra, P., Larrad, L., Piñeiro, A., Naval, J., Alava, M.A., Anel, A. Cell Growth Differ. (2002) [Pubmed]
 
WikiGenes - Universities