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Gene Review

SNX9  -  sorting nexin 9

Homo sapiens

Synonyms: Protein SDP1, SDP1, SH3 and PX domain-containing protein 1, SH3 and PX domain-containing protein 3A, SH3PX1, ...
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Disease relevance of SNX9


High impact information on SNX9


Biological context of SNX9


Anatomical context of SNX9


Associations of SNX9 with chemical compounds

  • Aldolase bound with high affinity to a tryptophan-containing acidic sequence in SNX9 located close to its Phox homology domain, thereby blocking the membrane binding activity of SNX9 [5].
  • Sorting nexin 9 (SNX9) belongs to a family of proteins, the sorting nexins, that are characterized by the presence of a subclass of the phosphoinositide-binding phox domain [8].
  • The interaction occurs between a proline-rich domain of ACK2 and the Src homology 3 domain (SH3) of SH3PX1 [11].
  • Dimerization is required for SH3PX1 tyrosine phosphorylation in response to epidermal growth factor signalling and interaction with ACK2 [12].
  • The total flavonoid recovery was around 80%, and it was practically not affected by the SDP1, SDP2, and SDP3 compositions [13].

Physical interactions of SNX9


Co-localisations of SNX9


Regulatory relationships of SNX9

  • The results suggest that SNX9-dependent recruitment of Dyn2 to the membrane is regulated by an interaction between SNX9 and aldolase [5].
  • Microinjection of 3T3L1 cells with an antibody against SNX9 inhibited stimulation by insulin of GLUT4 translocation [10].

Other interactions of SNX9


  1. EspF of enteropathogenic Escherichia coli binds sorting nexin 9. Marchès, O., Batchelor, M., Shaw, R.K., Patel, A., Cummings, N., Nagai, T., Sasakawa, C., Carlsson, S.R., Lundmark, R., Cougoule, C., Caron, E., Knutton, S., Connerton, I., Frankel, G. J. Bacteriol. (2006) [Pubmed]
  2. SUGAR-DEPENDENT1 encodes a patatin domain triacylglycerol lipase that initiates storage oil breakdown in germinating Arabidopsis seeds. Eastmond, P.J. Plant Cell (2006) [Pubmed]
  3. Interaction of the Wiskott-Aldrich syndrome protein with sorting nexin 9 is required for CD28 endocytosis and cosignaling in T cells. Badour, K., McGavin, M.K., Zhang, J., Freeman, S., Vieira, C., Filipp, D., Julius, M., Mills, G.B., Siminovitch, K.A. Proc. Natl. Acad. Sci. U.S.A. (2007) [Pubmed]
  4. SNX9 regulates dynamin assembly and is required for efficient clathrin-mediated endocytosis. Soulet, F., Yarar, D., Leonard, M., Schmid, S.L. Mol. Biol. Cell (2005) [Pubmed]
  5. Regulated membrane recruitment of dynamin-2 mediated by sorting nexin 9. Lundmark, R., Carlsson, S.R. J. Biol. Chem. (2004) [Pubmed]
  6. SNX9 as an adaptor for linking synaptojanin-1 to the Cdc42 effector ACK1. Yeow-Fong, L., Lim, L., Manser, E. FEBS Lett. (2005) [Pubmed]
  7. A 2.6 Mb interval on chromosome 6q25.2-q25.3 is commonly deleted in human nasal natural killer/T-cell lymphoma. Sun, H.S., Su, I.J., Lin, Y.C., Chen, J.S., Fang, S.Y. Br. J. Haematol. (2003) [Pubmed]
  8. Sorting nexin 9 participates in clathrin-mediated endocytosis through interactions with the core components. Lundmark, R., Carlsson, S.R. J. Biol. Chem. (2003) [Pubmed]
  9. Expression and properties of sorting nexin 9 in dynamin-mediated endocytosis. Lundmark, R., Carlsson, S.R. Meth. Enzymol. (2005) [Pubmed]
  10. Insulin stimulates movement of sorting nexin 9 between cellular compartments: a putative role mediating cell surface receptor expression and insulin action. MaCaulay, S.L., Stoichevska, V., Grusovin, J., Gough, K.H., Castelli, L.A., Ward, C.W. Biochem. J. (2003) [Pubmed]
  11. The Cdc42 target ACK2 interacts with sorting nexin 9 (SH3PX1) to regulate epidermal growth factor receptor degradation. Lin, Q., Lo, C.G., Cerione, R.A., Yang, W. J. Biol. Chem. (2002) [Pubmed]
  12. Dimerization is required for SH3PX1 tyrosine phosphorylation in response to epidermal growth factor signalling and interaction with ACK2. Childress, C., Lin, Q., Yang, W. Biochem. J. (2006) [Pubmed]
  13. The adjuvants aerosil 200 and Gelita-Sol-P influence on the technological characteristics of spray-dried powders from Passiflora edulis var. flavicarpa. De Souza, K.C., Petrovick, P.R., Bassani, V.L., Ortega, G.G. Drug development and industrial pharmacy. (2000) [Pubmed]
  14. A novel proteomic screen for peptide-protein interactions. Schulze, W.X., Mann, M. J. Biol. Chem. (2004) [Pubmed]
  15. The SCAN domain mediates selective oligomerization. Schumacher, C., Wang, H., Honer, C., Ding, W., Koehn, J., Lawrence, Q., Coulis, C.M., Wang, L.L., Ballinger, D., Bowen, B.R., Wagner, S. J. Biol. Chem. (2000) [Pubmed]
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