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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Iqgap1  -  IQ motif containing GTPase activating...

Mus musculus

Synonyms: AA682088, D7Ertd237e, D7Ertd257e, Ras GTPase-activating-like protein IQGAP1, mKIAA0051
 
 
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High impact information on Iqgap1

  • IQGAP-1 and rac-1 protein distribution changes from predominantly plasma membrane associated to predominantly cytoplasmic as the embryo progresses through cleavage divisions and compaction to the blastocyst stage [1].
  • Rac-1 and IQGAP are potential regulators of E-cadherin-catenin interactions during murine preimplantation development [2].
  • IQGAP1 is necessary for phagocytosis in mouse RAW macrophages through regulatory interactions with the actin nucleation factor mDia1 [3]
 

Anatomical context of Iqgap1

  • IQGAP-1 and rac-1 protein distribution changes from predominantly plasma membrane associated to predominantly cytoplasmic as the embryo progresses through cleavage divisions and compaction to the blastocyst stage [2].

References

  1. Rac-1 and IQGAP are potential regulators of E-cadherin-catenin interactions during murine preimplantation development. Natale, D.R., Watson, A.J. Mech. Dev. (2002) [Pubmed]
  2. Rac-1 and IQGAP are potential regulators of E-cadherin-catenin interactions during murine preimplantation development. Natale, D.R., Watson, A.J. Gene Expr. Patterns (2002) [Pubmed]
  3. Dia1 and IQGAP1 interact in cell migration and phagocytic cup formation. Brandt, D.T., Marion, S., Griffiths, G., Watanabe, T., Kaibuchi, K., Grosse, R. J. Cell. Biol. (2007) [Pubmed]
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