Rac-1 and IQGAP are potential regulators of E-cadherin-catenin interactions during murine preimplantation development.
Adherens junction formation is fundamental for compaction and trophectoderm differentiation during mammalian preimplantation development. We recently isolated an IQGAP-2 cDNA from a differential display-polymerase chain reaction screen of bovine preimplantation developmental stages. IQGAP-1 and -2 proteins mediate E-cadherin-based cell-to-cell adhesion through interactions with beta-catenin and the Rho GTPases, rac1 and cdc42. Our study demonstrates IQGAP-1,-2, rac-1 and cdc42 mRNAs are present throughout murine preimplantation development. IQGAP-1 and rac-1 protein distribution changes from predominantly plasma membrane associated to predominantly cytoplasmic as the embryo progresses through cleavage divisions and compaction to the blastocyst stage.[1]References
- Rac-1 and IQGAP are potential regulators of E-cadherin-catenin interactions during murine preimplantation development. Natale, D.R., Watson, A.J. Mech. Dev. (2002) [Pubmed]
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