Disease relevance of pid

• We show here that the nuclei of leukemia, lymphoma, and breast cancer cells could support normal preimplantation development to the blastocyst stage but failed to produce embryonic stem (ES) cells [1].
• Using somatic nuclear transfer, we show that medulloblastomas arising in Ptc1+/- mice can direct preimplantation development [2].
• These findings should help us understand organelle localization during mammalian oocyte maturation, and may give insights into possible causes of infertility and into early events of preimplantation development [3].
• The effect of Mycoplasma pulmonis on fertilization and preimplantation development in vitro of mouse eggs [4].
• Manifestations of diabetes mellitus on mouse preimplantation development: effect of elevated concentration of metabolic intermediates [5].

High impact information on pid

• Forskolin- and cholera toxin-activated adenylate cyclase activity increases between the morula and blastocyst stages of mouse preimplantation development, as assessed by the ability of these agents to increase embryonic cAMP levels [6].
• Mash-2 transcripts are found in the female germ line and in the embryo throughout preimplantation development, but are highly expressed later only in the ectoplacental cone, the chorion and their derivatives in the placenta [7].
• Human gene expression first occurs between the four- and eight-cell stages of preimplantation development [8].
• Haploid or diploid parthenogenones, resulting from spontaneous or experimental activation of unfertilized eggs, will undergo apparently normal preimplantation development but die in the early post-implantation stages [9].
• Chromosome methylation patterns during mammalian preimplantation development [10].

Chemical compound and disease context of pid

• The aim of study 3 was to define the limits of boric acid (BA) toxicity on mouse preimplantation development in vitro [11].

Biological context of pid

• A probe derived from this deletion fusion fragment defines a locus, D7Rn6, which maps within (or distal to) the pid region, and which discriminates among the distal extents of deletions eliciting the pid phenotype [12].
• Deletion mapping of four loci defined by N-ethyl-N-nitrosourea-induced postimplantation-lethal mutations within the pid-Hbb region of mouse chromosome 7 [13].
• Rats: significant retardation of preimplantation development and in early postimplantation stages; a tendency of lowering of the mean litter size [14].
• Structural relationship and posttranslational modification of stage-specific proteins synthesized during early preimplantation development in the mouse [15].
• During mouse preimplantation development, the exclusive expression of the Xist gene from the paternally inherited allele is thought to play a role in the inactivation of the paternally inherited X chromosome in the extra-embryonic cell lineages of the developing female embryo [16].

Anatomical context of pid

• Rats: significant increase of pathological, fragmented preimplantation embryos with a marked "litter effect". Mice: no deleterious effect upon preimplantation development [17].
• Thus, maternal E-cadherin suffices for initial compaction of the morula but not for further preimplantation development to occur [18].
• Enzyme analysis of these embryos revealed that TE cell nuclei could neither independently initiate or support preimplantation development [19].
• This finding raises the interesting question of whether ES cell lines derived from embryos at different stages of preimplantation development possess the same potential [20].
• To identify roles for complex and hybrid N-glycans in oogenesis and preimplantation development, the Mgat1 gene in oocytes was deleted by using a ZP3Cre recombinase transgene [21].

Associations of pid with chemical compounds

• Extension of physical maps from D7Rn6 should provide access both to the pid region and to loci mapping distal to pid that are defined by N-ethyl-N-nitrosourea-induced lethal mutations [12].
• The effect of ethanol upon early development in mice and rats. XIV. The effect of acute intoxication with beer and wine upon preimplantation development in rats [22].
• Levels of DNA MTase were found to be very high throughout preimplantation development even though levels of 5-methylcytosine (m5C) in nuclear DNA are known to undergo a substantial decline in the same period [23].
• Developmental expression and cellular localization of glucose transporter molecules during mouse preimplantation development [24].
• The roles of pyruvate, lactate and glucose during preimplantation development of embryos from F1 hybrid mice in vitro [25].

Physical interactions of pid

• Expression of fibronectin and a fibronectin-binding molecule during preimplantation development in the mouse [26].

Enzymatic interactions of pid

• Beta-catenin is a major tyrosine-phosphorylated protein during mouse oocyte maturation and preimplantation development [27].
• Two isoforms of ezrin phosphorylated on tyrosine residues are present during all of preimplantation development while a third non-tyrosine-phosphorylated isoform appears at the 8-cell stage and its relative amount increases from the 8-cell stage to the blastocyst stage [28].

Regulatory relationships of pid

• In normal XX embryos, maternally derived Xist alleles are repressed throughout preimplantation development [29].
• Here we show that three of the mouse Dishevelled proteins are not only expressed in oocytes and during preimplantation development, but also display distinct spatio-temporal localization [30].
• In the present study, we have investigated the stage-specific action and role of p38 MAPK in regulating filamentous actin during murine preimplantation development [31].
• Estrogen receptor and progesterone receptor genes are expressed differentially in mouse embryos during preimplantation development [32].
• Mitogen-activated protein kinase (MAPK) pathways mediate some important cellular processes and are likely to also regulate preimplantation development [33].

Other interactions of pid

• Of particular use for this mapping were preimplantation-lethal deletions having distal breakpoints localized between pid and Omp [13].
• The results obtained attest the prenatal noxious effect of chronic ethanol consumption in both species used and of acute ethanol intoxication during preimplantation development upon early postimplantation development in rats [34].
• These results suggest that maternal expression of Merc/Raly plays an important role in preimplantation development and that its deletion of is sufficient to explain Ay-associated embryonic lethality [35].
• Hmx3 null females can be fertilized and their embryos undergo normal preimplantation development, but the embryos fail to implant successfully in the Hmx3 null uterus and subsequently die [36].
• p38 MAPK signaling during murine preimplantation development [33].

Analytical, diagnostic and therapeutic context of pid

• We report modifications of the recently described mRNA differential display method (Liang, P. & Pardee, A. B. (1992) Science 257, 967-971) to analyze differential gene expression during mouse preimplantation development [37].
• The expression of nuclear lamins during mouse preimplantation development was studied by immunofluorescence, immunoblotting and immunoprecipitation [38].
• The Western blot results demonstrate that GLUT1 is detectable in the oocyte and throughout preimplantation development [24].
• The fate of nascent connexin43 was then followed throughout preimplantation development by means of laser confocal microscopy, using two other peptide (C-terminal)-specific antibodies [39].
• We have used peptide-specific antisera and the polymerase chain reaction to explore type-specific expression of these IAP during preimplantation development [40].

References