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Gene Review

HCFC2  -  host cell factor C2

Homo sapiens

Synonyms: C2 factor, HCF-2, HCF2, Host cell factor 2
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Disease relevance of HCFC2


High impact information on HCFC2

  • Here we describe the identification of a second HCF-like protein, designated HCF-2 [1].
  • HCF-2 is expressed in many tissues, especially the testis, and shows a more dynamic pattern of subcellular localization than HCF-1 [1].
  • HCF-2 is smaller than HCF-1 but shares three regions of strong amino acid sequence homology, including the beta-propeller domain required for association with VP16 [1].
  • Direct and indirect action mechanism of the C2 factor on the blood capillaries [2].


  1. Herpes simplex virus transactivator VP16 discriminates between HCF-1 and a novel family member, HCF-2. Johnson, K.M., Mahajan, S.S., Wilson, A.C. J. Virol. (1999) [Pubmed]
  2. Direct and indirect action mechanism of the C2 factor on the blood capillaries. Gazave, J.M., Roger, C., Achard, M., Parrot, J.L. Bibliotheca anatomica. (1975) [Pubmed]
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