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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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TIMM22  -  translocase of inner mitochondrial...

Homo sapiens

Synonyms: Mitochondrial import inner membrane translocase subunit Tim22, TEX4, TIM22, Testis-expressed sequence 4
 
 
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High impact information on TIMM22

  • At the inner membrane, the TIM23 (translocase of the inner membrane) mediates the import of mitochondrial proteins with a typical N-terminal targeting sequence, and the TIM22 complex mediates the import of polytopic inner membrane proteins [1].
  • Together with the Tim22 complex at the inner membrane, the small Tim proteins form the TIM22 import machinery that mediates the biogenesis of polytopic inner membrane proteins [2].
  • Two translocases have been characterized in the inner membrane: the Tim23-Tim17 complex and the Tim22 complex which differ in their specificities for preproteins [3].
 

Anatomical context of TIMM22

  • Nearly all mitochondrial proteins are synthesized in the cytosol and subsequently imported into mitochondria with the aid of translocators: the TOM complex in the outer membrane, and the TIM23 and TIM22 complexes in the inner membrane [4].
 

Physical interactions of TIMM22

  • Import of nuclear-encoded mitochondrial preproteins is mediated by a general translocase in the outer membrane, the TOM complex, and by two distinct translocases in the mitochondrial inner membrane, the TIM23 complex and the TIM22 complex [5].

References

  1. New developments in mitochondrial assembly. Koehler, C.M. Annu. Rev. Cell Dev. Biol. (2004) [Pubmed]
  2. The small Tim proteins and the twin Cx3C motif. Koehler, C.M. Trends Biochem. Sci. (2004) [Pubmed]
  3. Protein translocation into mitochondria. Káldi, K., Neupert, W. Biofactors (1998) [Pubmed]
  4. Functional cooperation and separation of translocators in protein import into mitochondria, the double-membrane bounded organelles. Endo, T., Yamamoto, H., Esaki, M. J. Cell. Sci. (2003) [Pubmed]
  5. Protein translocation into mitochondria: the role of TIM complexes. Bauer, M.F., Hofmann, S., Neupert, W., Brunner, M. Trends Cell Biol. (2000) [Pubmed]
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