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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

NRBP1  -  nuclear receptor binding protein 1

Homo sapiens

Synonyms: BCON3, MADM, MUDPNP, NRBP, Nuclear receptor-binding protein
 
 
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Disease relevance of NRBP1

 

High impact information on NRBP1

  • We further show that NRBP inhibits Jab1-induced phosphorylation of c-Jun and AP-1 activation [2].
  • The features of NRBP predict a function as an adapter protein potentially linking signaling pathways involving nuclear receptors and SH2 domain containing proteins [3].
  • The NRBP mRNA transcript, of approximately 2.4 kb, was ubiquitously expressed in a wide range of normal human tissues and 15 human tumor cell lines [3].
  • Immunocytochemistry showed that NRBP and activated Rac3 co-localized to endomembranes and at the cell periphery in lamellipodia [4].

References

  1. The non-structural 3 (NS3) protein of dengue virus type 2 interacts with human nuclear receptor binding protein and is associated with alterations in membrane structure. Chua, J.J., Ng, M.M., Chow, V.T. Virus Res. (2004) [Pubmed]
  2. Adapter protein NRBP associates with Jab1 and negatively regulates AP-1 activity. Wang, H., Sun, X., Luo, Y., Lin, Z., Wu, J. FEBS Lett. (2006) [Pubmed]
  3. Cloning of the cDNA and localization of the gene encoding human NRBP, a ubiquitously expressed, multidomain putative adapter protein. Hooper, J.D., Baker, E., Ogbourne, S.M., Sutherland, G.R., Antalis, T.M. Genomics (2000) [Pubmed]
  4. Interaction of the small GTPase Rac3 with NRBP, a protein with a kinase-homology domain. De Langhe, S., Haataja, L., Senadheera, D., Groffen, J., Heisterkamp, N. Int. J. Mol. Med. (2002) [Pubmed]
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