The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Editor

Share

Personal info

View

Links

  • Homologues
  • NCBI Gene
  • NCBI SNP
  • iHOP resource
  • SNPedia
  • UniProt

Table of contents

About

Terms

 

Gene Review: 

clocka  -  clock circadian regulator a

Danio rerio

Synonyms: SO:0000704, clock, zCLOCK1, zfCLOCK1
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

High impact information on clock

  • The expression of the Clock gene in zebrafish shows a strong circadian oscillation in many tissues in vivo and in culture, showing that endogenous oscillators exist in peripheral organs [1].
  • We also show that Clock, Bmal1, and Bmal2 all oscillate under LD and dark-dark conditions with similar kinetics, but only Clock is significantly induced while initiating a light-induced circadian oscillation in Z3 cells that have never been exposed to a LD cycle [2].
  • These results support the existence of independent peripheral oscillators and suggest that zfBMAL1 and zfBMAL2 may exert distinct circadian functions, interacting differentially with zfCLOCK at various times in different tissues [3].

References

  1. Light acts directly on organs and cells in culture to set the vertebrate circadian clock. Whitmore, D., Foulkes, N.S., Sassone-Corsi, P. Nature (2000) [Pubmed]
  2. A cell-based system that recapitulates the dynamic light-dependent regulation of the vertebrate clock. Pando, M.P., Pinchak, A.B., Cermakian, N., Sassone-Corsi, P. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  3. Asynchronous oscillations of two zebrafish CLOCK partners reveal differential clock control and function. Cermakian, N., Whitmore, D., Foulkes, N.S., Sassone-Corsi, P. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenesOpen Access LicencePrivacy PolicyTerms of Useapsburg
 
WikiGenes - Universities