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Gene Review:

CLOCK - clock homolog (mouse)

Gallus gallus

Larkin, P. et al., Hatori, M. et al.

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Disease relevance of CLOCK

In this study, we compared mRNA levels of iodopsin and the chicken homolog of Clock (cClock) in the retinas of normal and rd (retinal degeneration) chickens that lack functional rod and cone phototransduction cascades [1].

High impact information on CLOCK

The mRNA level of this gene exhibited robust diurnal change in the pineal gland, with a peak in the early (subjective) day under light-dark cycles and constant dark condition, and hence it was designated Lcg (Light-inducible and Clock-controlled Gene) [2].
Iodopsin is a circadian-regulated, photoreceptor-specific gene expressed in chicken retina, and Clock is a transcription factor that has been shown to play a role in the circadian clock mechanism in mouse and Drosophila [1].

References

Circadian regulation of iodopsin and clock is altered in the retinal degeneration chicken retina. Larkin, P., Baehr, W., Semple-Rowland, S.L. Brain Res. Mol. Brain Res. (1999) [Pubmed]
Lcg is a light-inducible and clock-controlled gene expressed in the chicken pineal gland. Hatori, M., Okano, T., Nakajima, Y., Doi, M., Fukada, Y. J. Neurochem. (2006) [Pubmed]

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CLOCK	Bos taurus
CLOCK	Canis lupus familiaris
clocka	Danio rerio
CLOCK	Homo sapiens
LOC697532	Macaca mulatta
Clock	Mus musculus
CLOCK	Pan troglodytes
Clock	Rattus norvegicus
clock	Xenopus (Silurana) tropicalis

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