The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

CLOCK  -  clock homolog (mouse)

Gallus gallus

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of CLOCK


High impact information on CLOCK

  • The mRNA level of this gene exhibited robust diurnal change in the pineal gland, with a peak in the early (subjective) day under light-dark cycles and constant dark condition, and hence it was designated Lcg (Light-inducible and Clock-controlled Gene) [2].
  • Iodopsin is a circadian-regulated, photoreceptor-specific gene expressed in chicken retina, and Clock is a transcription factor that has been shown to play a role in the circadian clock mechanism in mouse and Drosophila [1].


  1. Circadian regulation of iodopsin and clock is altered in the retinal degeneration chicken retina. Larkin, P., Baehr, W., Semple-Rowland, S.L. Brain Res. Mol. Brain Res. (1999) [Pubmed]
  2. Lcg is a light-inducible and clock-controlled gene expressed in the chicken pineal gland. Hatori, M., Okano, T., Nakajima, Y., Doi, M., Fukada, Y. J. Neurochem. (2006) [Pubmed]
WikiGenes - Universities