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Gene Review

hoxb5a  -  homeobox B5a

Danio rerio

Synonyms: Homeobox protein Hox-B5a, Homeobox protein Zf-21, Hox-B5, SO:0000704, ZF-21, ...
 
 
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High impact information on hoxb5a

  • We present evidence that a RA signal is necessary during pre-segmentation stages for proper expression of the spinal cord markers hoxb5a and hoxb6b, suggesting an influence of RA on anteroposterior patterning of the neural plate posterior to the hindbrain [1].
  • The region between the zebrafish homeobox genes hox-B5 and hox-B6 was sequenced, and searched for consensus binding sites of retinoic acid receptors and other transcription factors [2].
 

Analytical, diagnostic and therapeutic context of hoxb5a

References

  1. Retinoic acid signalling in the zebrafish embryo is necessary during pre-segmentation stages to pattern the anterior-posterior axis of the CNS and to induce a pectoral fin bud. Grandel, H., Lun, K., Rauch, G.J., Rhinn, M., Piotrowski, T., Houart, C., Sordino, P., Küchler, A.M., Schulte-Merker, S., Geisler, R., Holder, N., Wilson, S.W., Brand, M. Development (2002) [Pubmed]
  2. Sequence analysis of the zebrafish hox-B5/B6 region. Molven, A., Hordvik, I., Njølstad, P.R. Biochim. Biophys. Acta (1993) [Pubmed]
 
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