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Gene Review:

dlx4b - distal-less homeobox 4b

Danio rerio

Synonyms: DLX-7, Distal-less homeobox protein 4b, Homeobox protein Dlx4b, SO:0000704, dlx7, ...

Kaji, T. et al., Dutta, S. et al., Phillips, B.T. et al.

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High impact information on dlx4b

We show that pitx3 is required for pituitary pre-placode formation and cell specification, whereas dlx3b and dlx4b are required to restrict pituitary placode size [1].
At the same time, Msx-depletion restores normal preplacodal gene expression to dlx3b-dlx4b mutants [2].
dlx3b and dlx4b function in the development of Rohon-Beard sensory neurons and trigeminal placode in the zebrafish neurula [3].

Anatomical context of dlx4b

Inhibition of dlx3b and dlx4b protein and activity resulted in the reduction or complete loss of Rohon-Beard (RB) sensory neurons and trigeminal (TG) sensory placodes [3].

References

pitx3 defines an equivalence domain for lens and anterior pituitary placode. Dutta, S., Dietrich, J.E., Aspöck, G., Burdine, R.D., Schier, A., Westerfield, M., Varga, Z.M. Development (2005) [Pubmed]
Zebrafish msxB, msxC and msxE function together to refine the neural-nonneural border and regulate cranial placodes and neural crest development. Phillips, B.T., Kwon, H.J., Melton, C., Houghtaling, P., Fritz, A., Riley, B.B. Dev. Biol. (2006) [Pubmed]
dlx3b and dlx4b function in the development of Rohon-Beard sensory neurons and trigeminal placode in the zebrafish neurula. Kaji, T., Artinger, K.B. Dev. Biol. (2004) [Pubmed]

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