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Gene Review:

pitx3 - paired-like homeodomain 3

Danio rerio

Synonyms: Bicoid-like homeodomain transcription factor Pitx3, Homeobox protein PITX3, Paired-like homeodomain transcription factor 3, Pituitary homeobox 3, SO:0000704, ...

Zilinski, C.A. et al., Dutta, S. et al., Shi, X. et al., Shi, X. et al.

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High impact information on pitx3

We analyzed pituitary precursor cell lineages and find that pitx3 and distal-less3b (dlx3b) expression domains define lens and pituitary precursor positions [1].
We show that pitx3 is required for pituitary pre-placode formation and cell specification, whereas dlx3b and dlx4b are required to restrict pituitary placode size [1].
Zebrafish foxe3: Roles in ocular lens morphogenesis through interaction with pitx3 [2].
Modulation of zebrafish pitx3 expression in the primordia of the pituitary, lens, olfactory epithelium and cranial ganglia by hedgehog and nodal signaling [3].
While the lens and trigeminal placodes express pitx3 in the absence of hedgehog and nodal signaling, there is no expression of pitx3 in the anteriormost ectoderm adjacent to the neural plate from which the anterior pituitary would derive [3].

Analytical, diagnostic and therapeutic context of pitx3

Expression of the zebrafish pitx3 gene was studied by in situ mRNA hybridization and RT-PCR [4].

References

pitx3 defines an equivalence domain for lens and anterior pituitary placode. Dutta, S., Dietrich, J.E., Aspöck, G., Burdine, R.D., Schier, A., Westerfield, M., Varga, Z.M. Development (2005) [Pubmed]
Zebrafish foxe3: Roles in ocular lens morphogenesis through interaction with pitx3. Shi, X., Luo, Y., Howley, S., Dzialo, A., Foley, S., Hyde, D.R., Vihtelic, T.S. Mech. Dev. (2006) [Pubmed]
Modulation of zebrafish pitx3 expression in the primordia of the pituitary, lens, olfactory epithelium and cranial ganglia by hedgehog and nodal signaling. Zilinski, C.A., Shah, R., Lane, M.E., Jamrich, M. Genesis (2005) [Pubmed]
Zebrafish pitx3 is necessary for normal lens and retinal development. Shi, X., Bosenko, D.V., Zinkevich, N.S., Foley, S., Hyde, D.R., Semina, E.V., Vihtelic, T.S. Mech. Dev. (2005) [Pubmed]

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