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Gene Review

vsx1  -  visual system homeobox 1 homolog, chx10-like

Danio rerio

Synonyms: SO:0000704, Transcription factor VSX1, Visual system homeobox 1
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High impact information on vsx1

  • The combined expression patterns of teleost vsx1 and vsx2 (alx) during early zebrafish development encompasses the expression pattern observed for murine Chx10, and indicates a partitioning of function for CVC genes in lower vertebrates [1].
  • vsx1 is a homeobox gene encoding a paired-type homeodomain and a CVC domain that was originally cloned from an adult goldfish retinal library [1].
  • At about the same time that retinal expression began, the level of vsx1 was decreased in the spinal cord [1].
  • We previously reported the spatiotemporal expression pattern of vsx1 in the adult and developing retina of zebrafish and goldfish, and we suggested that vsx1 plays a role in determining the cell fate and maintenance of retinal interneurons [1].


  1. Cloning of zebrafish vsx1: expression of a paired-like homeobox gene during CNS development. Passini, M.A., Kurtzman, A.L., Canger, A.K., Asch, W.S., Wray, G.A., Raymond, P.A., Schechter, N. Dev. Genet. (1998) [Pubmed]
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