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Gene Review

msxc  -  muscle segment homeobox C

Danio rerio

Synonyms: Homeobox protein MSH-C, SO:0000704, homeobox, msh-C, msh-c, ...
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Disease relevance of msxc

  • Mutations in the homeobox gene vHnf1 are associated with human diseases MODY5 (maturity-onset diabetes of the young, type V) and familial GCKD (glomerulocystic kidney disease) [1].

High impact information on msxc


Biological context of msxc


Anatomical context of msxc

  • The zebrafish muscle segment homeobox genes msxB, msxC and msxE are expressed in partially overlapping domains in the neural crest and preplacodal ectoderm [11].
  • We conclude that the patterned distribution of different primary motoneuronal types within the zebrafish spinal cord follows the patterned expression of LIM homeobox genes, and that this reflects a highly resolved system of positional information controlling gene transcription [8].
  • Mezzo, a paired-like homeobox protein is an immediate target of Nodal signalling and regulates endoderm specification in zebrafish [12].
  • Zebrafish embryos compromised in Hh signaling exhibit disruption in the expression of the pancreas-specifying homeobox gene pdx-1 and concomitantly show almost complete absence of the endocrine pancreas [13].
  • The homeobox gene Prox 1, which is expressed in the expanded taste buds and cranial neuromasts, is one of the genes involved in the constructive changes in sensory organ development [14].

Regulatory relationships of msxc


Other interactions of msxc

  • We suggest that combinatorial expression of the dlx genes is part of a homeobox gene code specifying pattern formation or cell fate determination in the forebrain, in peripheral structures of the head, and in the fins [16].
  • vsx1 is a homeobox gene encoding a paired-type homeodomain and a CVC domain that was originally cloned from an adult goldfish retinal library [17].
  • We previously reported that, while several ventral cells initially express the zebrafish Islet-1 (Isl-1) gene, a member of the LIM/homeobox gene family, the expression of this gene becomes restricted to a single or a pair of cells slightly anterior to each segment border by 16 hr after fertilization [18].
  • Functional and hierarchical interactions among zebrafish vox/vent homeobox genes [19].
  • A homeobox gene, pnx, is involved in the formation of posterior neurons in zebrafish [20].

Analytical, diagnostic and therapeutic context of msxc


  1. vhnf1, the MODY5 and familial GCKD-associated gene, regulates regional specification of the zebrafish gut, pronephros, and hindbrain. Sun, Z., Hopkins, N. Genes Dev. (2001) [Pubmed]
  2. A novel homeobox gene, dharma, can induce the organizer in a non-cell-autonomous manner. Yamanaka, Y., Mizuno, T., Sasai, Y., Kishi, M., Takeda, H., Kim, C.H., Hibi, M., Hirano, T. Genes Dev. (1998) [Pubmed]
  3. Regional expression of three homeobox transcripts in the inner ear of zebrafish embryos. Ekker, M., Akimenko, M.A., Bremiller, R., Westerfield, M. Neuron (1992) [Pubmed]
  4. Homez, a homeobox leucine zipper gene specific to the vertebrate lineage. Bayarsaihan, D., Enkhmandakh, B., Makeyev, A., Greally, J.M., Leckman, J.F., Ruddle, F.H. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  5. Ol-Prx 3, a member of an additional class of homeobox genes, is unimodally expressed in several domains of the developing and adult central nervous system of the medaka (Oryzias latipes). Joly, J.S., Bourrat, F., Nguyen, V., Chourrout, D. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  6. Cloning and evolutionary analysis of msh-like homeobox genes from mouse, zebrafish and ascidian. Holland, P.W. Gene (1991) [Pubmed]
  7. Nuclear export is evolutionarily conserved in CVC paired-like homeobox proteins and influences protein stability, transcriptional activation, and extracellular secretion. Knauer, S.K., Carra, G., Stauber, R.H. Mol. Cell. Biol. (2005) [Pubmed]
  8. Motoneuron fate specification revealed by patterned LIM homeobox gene expression in embryonic zebrafish. Appel, B., Korzh, V., Glasgow, E., Thor, S., Edlund, T., Dawid, I.B., Eisen, J.S. Development (1995) [Pubmed]
  9. Specification of cell fates at the dorsal margin of the zebrafish gastrula. Melby, A.E., Warga, R.M., Kimmel, C.B. Development (1996) [Pubmed]
  10. Presence of isl-1-related LIM domain homeobox genes in teleost and their similar patterns of expression in brain and spinal cord. Gong, Z., Hui, C.C., Hew, C.L. J. Biol. Chem. (1995) [Pubmed]
  11. Zebrafish msxB, msxC and msxE function together to refine the neural-nonneural border and regulate cranial placodes and neural crest development. Phillips, B.T., Kwon, H.J., Melton, C., Houghtaling, P., Fritz, A., Riley, B.B. Dev. Biol. (2006) [Pubmed]
  12. Mezzo, a paired-like homeobox protein is an immediate target of Nodal signalling and regulates endoderm specification in zebrafish. Poulain, M., Lepage, T. Development (2002) [Pubmed]
  13. Hedgehog signaling pathway is essential for pancreas specification in the zebrafish embryo. Roy, S., Qiao, T., Wolff, C., Ingham, P.W. Curr. Biol. (2001) [Pubmed]
  14. Cavefish as a model system in evolutionary developmental biology. Jeffery, W.R. Dev. Biol. (2001) [Pubmed]
  15. T-box gene eomesodermin and the homeobox-containing Mix/Bix gene mtx2 regulate epiboly movements in the zebrafish. Bruce, A.E., Howley, C., Dixon Fox, M., Ho, R.K. Dev. Dyn. (2005) [Pubmed]
  16. Combinatorial expression of three zebrafish genes related to distal-less: part of a homeobox gene code for the head. Akimenko, M.A., Ekker, M., Wegner, J., Lin, W., Westerfield, M. J. Neurosci. (1994) [Pubmed]
  17. Cloning of zebrafish vsx1: expression of a paired-like homeobox gene during CNS development. Passini, M.A., Kurtzman, A.L., Canger, A.K., Asch, W.S., Wray, G.A., Raymond, P.A., Schechter, N. Dev. Genet. (1998) [Pubmed]
  18. Molecular heterogeneity among primary motoneurons and within myotomes revealed by the differential mRNA expression of novel islet-1 homologs in embryonic zebrafish. Tokumoto, M., Gong, Z., Tsubokawa, T., Hew, C.L., Uyemura, K., Hotta, Y., Okamoto, H. Dev. Biol. (1995) [Pubmed]
  19. Functional and hierarchical interactions among zebrafish vox/vent homeobox genes. Gilardelli, C.N., Pozzoli, O., Sordino, P., Matassi, G., Cotelli, F. Dev. Dyn. (2004) [Pubmed]
  20. A homeobox gene, pnx, is involved in the formation of posterior neurons in zebrafish. Bae, Y.K., Shimizu, T., Yabe, T., Kim, C.H., Hirata, T., Nojima, H., Muraoka, O., Hirano, T., Hibi, M. Development (2003) [Pubmed]
  21. Homeobox genes in the Australian lungfish, Neoceratodus forsteri. Longhurst, T.J., Joss, J.M. J. Exp. Zool. (1999) [Pubmed]
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