Disease relevance of msxc

• Mutations in the homeobox gene vHnf1 are associated with human diseases MODY5 (maturity-onset diabetes of the young, type V) and familial GCKD (glomerulocystic kidney disease) [1].

High impact information on msxc

• In this report we have isolated a novel zebrafish homeobox gene, dharma, capable of inducing the organizer ectopically [2].
• Even later, sensory hair cells express msh-C and msh-D, while other cells of the epithelium express dlx-3 [3].
• Regional expression of three homeobox transcripts in the inner ear of zebrafish embryos [3].
• Homez, a homeobox leucine zipper gene specific to the vertebrate lineage [4].
• Ol-Prx 3, a member of an additional class of homeobox genes, is unimodally expressed in several domains of the developing and adult central nervous system of the medaka (Oryzias latipes) [5].

Biological context of msxc

• The homeobox is a relatively conserved 180-nucleotide-long sequence characterizing a large and phylogenetically wide-spread family of putative regulatory genes, many of which have been implicated in the control of embryonic development [6].
• Nuclear export is evolutionarily conserved in CVC paired-like homeobox proteins and influences protein stability, transcriptional activation, and extracellular secretion [7].
• Motoneuron fate specification revealed by patterned LIM homeobox gene expression in embryonic zebrafish [8].
• The borders of the notochord domain are sharp at the level of single cells, and coincide almost exactly with the border of the expression domain of the homeobox gene floating head (flh; zebrafish homologue of Xnot), a gene essential for notochord development [9].
• Three novel LIM domain homeobox cDNAs encoding proteins structurally related to the Isl-1 protein were isolated from a chinook salmon pituitary cDNA library [10].

Anatomical context of msxc

• The zebrafish muscle segment homeobox genes msxB, msxC and msxE are expressed in partially overlapping domains in the neural crest and preplacodal ectoderm [11].
• We conclude that the patterned distribution of different primary motoneuronal types within the zebrafish spinal cord follows the patterned expression of LIM homeobox genes, and that this reflects a highly resolved system of positional information controlling gene transcription [8].
• Mezzo, a paired-like homeobox protein is an immediate target of Nodal signalling and regulates endoderm specification in zebrafish [12].
• Zebrafish embryos compromised in Hh signaling exhibit disruption in the expression of the pancreas-specifying homeobox gene pdx-1 and concomitantly show almost complete absence of the endocrine pancreas [13].
• The homeobox gene Prox 1, which is expressed in the expanded taste buds and cranial neuromasts, is one of the genes involved in the constructive changes in sensory organ development [14].

Regulatory relationships of msxc

• We also show that eomes regulates the expression of a zygotic homeobox transcription factor mtx2 [15].

Other interactions of msxc

• We suggest that combinatorial expression of the dlx genes is part of a homeobox gene code specifying pattern formation or cell fate determination in the forebrain, in peripheral structures of the head, and in the fins [16].
• vsx1 is a homeobox gene encoding a paired-type homeodomain and a CVC domain that was originally cloned from an adult goldfish retinal library [17].
• We previously reported that, while several ventral cells initially express the zebrafish Islet-1 (Isl-1) gene, a member of the LIM/homeobox gene family, the expression of this gene becomes restricted to a single or a pair of cells slightly anterior to each segment border by 16 hr after fertilization [18].
• Functional and hierarchical interactions among zebrafish vox/vent homeobox genes [19].
• A homeobox gene, pnx, is involved in the formation of posterior neurons in zebrafish [20].

Analytical, diagnostic and therapeutic context of msxc

• Since lungfish have extremely large genomes, we took the approach of extracting pure high molecular weight (MW) genomic DNA to act as a template for polymerase chain reaction (PCR) of the conserved homeobox domain of the highly conserved Hox genes [21].

References