The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

PLA2G2E  -  phospholipase A2, group IIE

Homo sapiens

Synonyms: GIIE sPLA2, Group IIE secretory phospholipase A2, Phosphatidylcholine 2-acylhydrolase 2E, sPLA2-IIE
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of PLA2G2E


High impact information on PLA2G2E

  • The enzymatic properties of recombinant human sPLA(2)-IIE were almost identical to those of sPLA(2)-IIA and IID in terms of Ca(2+) requirement, optimal pH, substrate specificity, as well as high susceptibility to the sPLA(2) inhibitor indoxam [2].
  • We also find that sPLA(2)-IIE, -V, and -X are differentially induced by kainic acid [3].
  • The distribution of sPLA(2)-IIE, V, and -X seems to be mainly neuronal, with the highest abundance occurring in the cerebral cortex and hippocampus [3].

Analytical, diagnostic and therapeutic context of PLA2G2E

  • In situ hybridization analysis revealed elevation of sPLA(2)-IIE mRNA at alveolar macrophage-like cells in the lung of endotoxin-treated mice [2].


  1. Arachidonate release and eicosanoid generation by group IIE phospholipase A(2). Murakami, M., Yoshihara, K., Shimbara, S., Lambeau, G., Singer, A., Gelb, M.H., Sawada, M., Inagaki, N., Nagai, H., Kudo, I. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  2. Structures, enzymatic properties, and expression of novel human and mouse secretory phospholipase A(2)s. Suzuki, N., Ishizaki, J., Yokota, Y., Higashino, K., Ono, T., Ikeda, M., Fujii, N., Kawamoto, K., Hanasaki, K. J. Biol. Chem. (2000) [Pubmed]
  3. Characterization and location of secretory phospholipase A2 groups IIE, V, and X in the rat brain. Kolko, M., Christoffersen, N.R., Barreiro, S.G., Miller, M.L., Pizza, A.J., Bazan, N.G. J. Neurosci. Res. (2006) [Pubmed]
WikiGenes - Universities