Disease relevance of Hypertension, Pulmonary

• CONCLUSIONS: Pulmonary hypertension in association with hereditary hemorrhagic telangiectasia can involve mutations in ALK1 [1].
• To test the hypothesis that chronic infusion of atrial natriuretic peptide (ANP) instituted before hypoxic exposure attenuates the development of pulmonary hypertension in hypoxia adapted rats, ANP (0.2 and 1.0 microgram/h) or vehicle was administered intravenously via osmotic minipump for 4 wk beginning before exposure to 10% O2 or to room air [2].
• Specifically, preincubation of platelets with imidazole, a thromboxane synthetase blocker, prior to infusion with AGEPC significantly diminished pulmonary hypertension and prevented lung edema [3].
• Sildenafil for lung fibrosis and pulmonary hypertension [4].
• OBJECTIVE: To ascertain whether pulmonary hypertension, as assessed noninvasively by continuous-wave Doppler of tricuspid regurgitation, can be an important independent factor in the prognosis of patients with ischemic or idiopathic dilated cardiomyopathy [5].

Psychiatry related information on Hypertension, Pulmonary

• Three forms of pulmonary hypertension (PH) exist, including PPH, FPPH, and PH secondary to other etiologies (sporadic PH) such as drug abuse and human immunodeficiency virus (HIV) infection [6].
• With accumulating evidence of benefits on endothelial function and clinical improvements in pulmonary hypertension and heart failure, the hemodynamic and exercise effects of PDE5 inhibitors suggest an important therapeutic cardiovascular role, reinforcing their safety in the patient with CAD and erectile dysfunction [7].

High impact information on Hypertension, Pulmonary

• CONCLUSIONS: Infants with persistent pulmonary hypertension have low plasma concentrations of arginine and nitric oxide metabolites [8].
• Recently, aerosolized iloprost, a stable prostacyclin analogue, has been introduced as an alternative therapy for severe pulmonary hypertension [9].
• Low-dose nitric oxide therapy for persistent pulmonary hypertension of the newborn. Clinical Inhaled Nitric Oxide Research Group [10].
• Fatal pulmonary hypertension associated with short-term use of fenfluramine and phentermine [11].
• Endothelin-1 in pulmonary hypertension [12].

Chemical compound and disease context of Hypertension, Pulmonary

• Thromboxane and prostacyclin metabolites in pulmonary hypertension [13].
• An increase in the release of the vasoconstrictor thromboxane A2, suggesting the activation of platelets, occurs in both the primary and secondary forms of pulmonary hypertension [14].
• Isoproterenol in pulmonary hypertension [15].
• Complete reversal of fatal pulmonary hypertension in rats by a serine elastase inhibitor [16].
• To test this, we delivered inhaled sodium nitrite by aerosol to newborn lambs with hypoxic and normoxic pulmonary hypertension [17].

Biological context of Hypertension, Pulmonary

• RESULTS: We identified suggestive linkage of pulmonary hypertension with hereditary hemorrhagic telangiectasia on chromosome 12q13, a region that includes ALK1 [1].
• Progression of pulmonary hypertension is associated with increased serine elastase activity and the proteinase-dependent deposition of the extracellular matrix smooth muscle cell survival factor tenascin-C (refs. 1,2) [16].
• Persistence of the fetal pattern of tropoelastin gene expression in severe neonatal bovine pulmonary hypertension [18].
• We conclude that pulmonary hypertension in the neonate perturbs the normal postpartum repression of tropoelastin expression resulting in a persistence of the fetal spacial and isoform patterns of tropoelastin gene expression [18].
• INTERPRETATION: Sildenafil causes preferential pulmonary vasodilation and improves gas exchange in patients with severe lung fibrosis and secondary pulmonary hypertension [19].

Anatomical context of Hypertension, Pulmonary

• In the lungs, the endothelin system regulates the tone of airways and blood vessels, and it is involved in the development of pulmonary hypertension [20].
• Neonatal hypoxic pulmonary hypertension causes increases and spatial changes in tropoelastin expression in pulmonary arteries [18].
• We conclude that low-dose infusion of nitroglycerin reduces the pulmonary vascular resistance in patients with pulmonary hypertension, and consequently results in improvement in immediate postoperative hemodynamics after replacement of a stenotic mitral valve [21].
• The appearance of the right ventricular myocardium on thallium 201 myocardial perfusion images was evaluated in patients with chronic pulmonary hypertension and compared to patients without pulmonary hypertension [22].
• To investigate this relation, we performed immunofluorescent antinuclear antibody tests (ANA) and serological human leukocyte antigen (HLA)-A, B, C, DR, and DQ typing on two groups of Caucasian children with unexplained pulmonary hypertension (PHT) and their parents [23].

Gene context of Hypertension, Pulmonary

• In lung tissues and PASMC from IPAH patients, the mRNA and protein expression of TRPC3 and -6 were much higher than in those from normotensive or secondary pulmonary hypertension patients [24].
• Endothelin receptor antagonists in a beagle model of pulmonary hypertension: contribution to possible potential therapy [25]?
• Recently, a cause for familial primary pulmonary hypertension (FPPH) has been identified as mutations in the gene encoding BMPR2 [6].
• In humans, induction of COX-2 during pulmonary hypertension may be beneficial for long-term treatment of this disease [26].
• Interleukin-1 receptor antagonist treatment reduces pulmonary hypertension generated in rats by monocrotaline [27].

Analytical, diagnostic and therapeutic context of Hypertension, Pulmonary

• To explore this notion further, the authors evaluated the effects of the PDGF receptor inhibitor STI571 in 2 different animal models of pulmonary hypertension [28].
• OBJECTIVE: To describe exercise capacity, functional class, and hemodynamic variables after long-term intravenous infusion of prostacyclin in patients with secondary pulmonary hypertension [29].
• Venous plasma immunoreactive endothelin-1, measured by a specific radioimmunoassay, was significantly higher in patients with pulmonary hypertension (3.5 +/- 2.5 pg/mL, P less than 0.001) than in normal subjects (1.45 +/- 0.45 pg/mL), or patients with coronary disease (0.75 +/- 0.64 pg/mL) [30].
• Use of inhaled nitric oxide and acetylcholine in the evaluation of pulmonary hypertension and endothelial function after cardiopulmonary bypass [31].
• B23 seropositivity was related to pulmonary hypertension, antifibrillarin antibody, anti-RNP antibody, and decreased lung capacity [32].

Chemical compound and disease context of Hypertension, Pulmonary

• N-terminal pro brain natriuretic peptide measurements reflect changes in magnetic resonance imaging-measured right ventricular structure and function in pulmonary hypertension patients [33].

References