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Gene Review

Cngb3  -  cyclic nucleotide gated channel beta 3

Mus musculus

Synonyms: CCNC2, CNG channel beta-3, CNG6, Cng6, Cngbeta2, ...
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High impact information on Cngb3

  • Taken together, the data indicate that CNG6 represents a new CNG channel beta subunit that may associate with the CNG3 alpha subunit to form the native cone channel [1].
  • However, when coexpressed with the cone photoreceptor alpha subunit, CNG6 induced a flickering channel gating, weakened the outward rectification in the presence of extracellular Ca(2+), increased the sensitivity for L-cis diltiazem, and enhanced the cAMP efficacy of the channel [1].
  • CNG6 transcripts are present in a small subset of retinal photoreceptor cells and also in testis [1].

Analytical, diagnostic and therapeutic context of Cngb3


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