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Gene Review:

sctU - type III secretion system protein HrcU

Burkholderia pseudomallei K96243

Winstanley, C. et al., Smith-Vaughan, H.C. et al.

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Disease relevance of sctU

Dot blot hybridization and PCR amplification of 14 Ara(+) and 8 Ara(-) Burkholderia pseudomallei strains showed that type III secretion (TTS) genes were present in all the Ara(-) strains but absent from all but one of the Ara(+) strains [1].

High impact information on sctU

Type III secretion (TTSI) genes of an HRP (hypersensitivity response and pathogenicity)-like locus were present in all 116 Northern Australian Burkholderia pseudomallei isolates tested but were not detected in other common environmental Burkholderia species [2].
The link between TTS genes and an Ara(-) phenotype suggests a role for TTS in virulence [1].

References

Presence of type III secretion genes in Burkholderia pseudomallei correlates with Ara(-) phenotypes. Winstanley, C., Hart, C.A. J. Clin. Microbiol. (2000) [Pubmed]
Ubiquity of putative type III secretion genes among clinical and environmental Burkholderia pseudomallei isolates in Northern Australia. Smith-Vaughan, H.C., Gal, D., Lawrie, P.M., Winstanley, C., Sriprakash, K.S., Currie, B.J. J. Clin. Microbiol. (2003) [Pubmed]

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