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Gene Review

l(1)sc  -  lethal of scute

Drosophila melanogaster

Synonyms: AS-C T3, AS-T3, ASC-T3, Achaete-scute complex protein T3, CG3839, ...
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High impact information on l(1)sc

  • Loss-of-function and overexpression phenotypes indicate a role for l'sc in the segregation of muscle progenitors and the formation of the muscle pattern [1].
  • We show that the proneural gene lethal of scute (l'sc) is expressed in clusters of cells in the somatic mesoderm, from which individual muscle progenitors are singled out by progressive restriction of l'sc expression [1].
  • The lethal of scute (l'sc) genetic function, which plays an essential role in the early development of the central nervous system of the Drosophila embryo, is localized within the achaete-scute complex (AS-C) [2].
  • Rate constancy of DNA sequence evolution was examined for three species of Drosophila, using two samples: the published sequences of eight genes from regions of the normal recombination rates and new data of the four AS-C (ac, sc, l'sc and ase) and ci genes [3].
  • Ectopic expression, under control of the GAL4 system, of the proneural gene lethal of scute (l'sc) causes the development of ectopic bristles [4].

Biological context of l(1)sc

  • We demonstrate that short fragments of DNA, containing the T3 transcribed region and a few kilobases of flanking sequences, rescue, albeit partially, the lethality and neural phenotype of l'sc deletions [2].
  • Based upon the expression pattern of the proneural gene lethal of scute (l'sc), as well as the pattern of brain neuroblast segregation, the protocerebral and deuterocerebral neuromeres can be further subdivided into a central, anterior, and posterior domain [5].

Other interactions of l(1)sc

  • The Drosophila adult has one pair of legs on each of its three thoracic segments (the T1-T3 segments) [6].


  1. Lethal of scute, a proneural gene, participates in the specification of muscle progenitors during Drosophila embryogenesis. Carmena, A., Bate, M., Jiménez, F. Genes Dev. (1995) [Pubmed]
  2. Molecular characterization of the lethal of scute genetic function. Martín-Bermudo, M.D., González, F., Domínguez, M., Rodríguez, I., Ruiz-Gómez, M., Romani, S., Modolell, J., Jiménez, F. Development (1993) [Pubmed]
  3. Rate variation of DNA sequence evolution in the Drosophila lineages. Takano, T.S. Genetics (1998) [Pubmed]
  4. A genetic screen for elements of the network that regulates neurogenesis in Drosophila. Röttgen, G., Wagner, T., Hinz, U. Mol. Gen. Genet. (1998) [Pubmed]
  5. Early neurogenesis of the Drosophila brain. Younossi-Hartenstein, A., Nassif, C., Green, P., Hartenstein, V. J. Comp. Neurol. (1996) [Pubmed]
  6. Differential Delta expression underlies the diversity of sensory organ patterns among the legs of the Drosophila adult. Shroff, S., Joshi, M., Orenic, T.V. Mech. Dev. (2007) [Pubmed]
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