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Gene Review

ase  -  asense

Drosophila melanogaster

Synonyms: AS-C T8, AS-C T8ase, AS-T8, ASC, Achaete-scute complex protein T8, ...
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Psychiatry related information on ase


High impact information on ase

  • The GATA factor Pannier activates the achaete-scute (ASC) proneural complex through enhancer binding and provides positional information for sensory bristle patterning in Drosophila [2].
  • These defects, which include malformations of the external part of the SOs, duplication of the innervating neuron etc, are enhanced by the haploid condition for the other AS-C genes and are corrected by an ase transgene [3].
  • The asense (ase) gene of the achaete-scute complex (AS-C) is expressed in the precursors of all adult sensory organs (SOs), the sensory mother cells (SMCs) and in their immediate progeny [3].
  • In the embryo, ase is expressed in neural precursor cells, a pattern consistent with the known requirement of sc gamma for the development of the larval nervous system [4].
  • Molecular analysis of the asense gene, a member of the achaete-scute complex of Drosophila melanogaster, and its novel role in optic lobe development [4].

Biological context of ase

  • Rate constancy of DNA sequence evolution was examined for three species of Drosophila, using two samples: the published sequences of eight genes from regions of the normal recombination rates and new data of the four AS-C (ac, sc, l'sc and ase) and ci genes [5].
  • Mutations at some candidate loci (bb, emc, h, Dl, Hairless) showed strong interactions with selected chromosomes, whereas others interacted weakly (ASC, abd, Scr) or not at all (N, mab, E(spl)) [6].
  • We have identified a mutant asense phenotype that may reflect this later expression pattern [7].
  • Delection of these sites reduces the expression from the fusion gene, but significant expression is still achieved, pointing to the existence of other regulators of asense in addition to the AS-C. asense differs from the other AS-C members in its expression pattern, regulation, mutant phenotype and some DNA-binding properities [7].

Anatomical context of ase

  • Genes of the achaete-scute complex (ASC) participate in the formation of the central nervous system in the Drosophila embryo [8].

Regulatory relationships of ase


Other interactions of ase

  • This phenomenon seems instead to be related to their shared ability to activate Asense and Senseless [10].
  • With respect to their position and the expression of the markers asense (ase) and seven-up (svp), 23 small groups of one to five neuroblasts each were identified [11].
  • The AS-C may have arisen from a single sc/l'sc like gene which is well conserved in Apis and Anopheles and a second ase like gene that is highly diverged, however, located within 50 kb [12].
  • Unlike the other AS-C members, which are expressed in subsets of the ectodermal areas (proneural clusters) that give rise to neural precursors, asense is one of a number of genes that are specifically expressed in the neural precursors themselves (neural precursor genes) [7].
  • Consistent with these observations endogenous Deadpan is expressed in mitotic areas of the optic lobes, and endogenous Asense is expressed in cells that will become quiescent [9].


  1. The EGF receptor and N signalling pathways act antagonistically in Drosophila mesothorax bristle patterning. Culí, J., Martín-Blanco, E., Modolell, J. Development (2001) [Pubmed]
  2. Interactions between chip and the achaete/scute-daughterless heterodimers are required for pannier-driven proneural patterning. Ramain, P., Khechumian, R., Khechumian, K., Arbogast, N., Ackermann, C., Heitzler, P. Mol. Cell (2000) [Pubmed]
  3. asense, a member of the Drosophila achaete-scute complex, is a proneural and neural differentiation gene. Domínguez, M., Campuzano, S. EMBO J. (1993) [Pubmed]
  4. Molecular analysis of the asense gene, a member of the achaete-scute complex of Drosophila melanogaster, and its novel role in optic lobe development. González, F., Romani, S., Cubas, P., Modolell, J., Campuzano, S. EMBO J. (1989) [Pubmed]
  5. Rate variation of DNA sequence evolution in the Drosophila lineages. Takano, T.S. Genetics (1998) [Pubmed]
  6. Genetic interactions between naturally occurring alleles at quantitative trait loci and mutant alleles at candidate loci affecting bristle number in Drosophila melanogaster. Long, A.D., Mullaney, S.L., Mackay, T.F., Langley, C.H. Genetics (1996) [Pubmed]
  7. The regulation and function of the helix-loop-helix gene, asense, in Drosophila neural precursors. Jarman, A.P., Brand, M., Jan, L.Y., Jan, Y.N. Development (1993) [Pubmed]
  8. Distribution and function of the lethal of scute gene product during early neurogenesis in Drosophila. Martín-Bermudo, M.D., Martínez, C., Rodríguez, A., Jiménez, F. Development (1991) [Pubmed]
  9. The pan-neural bHLH proteins DEADPAN and ASENSE regulate mitotic activity and cdk inhibitor dacapo expression in the Drosophila larval optic lobes. Wallace, K., Liu, T.H., Vaessin, H. Genesis (2000) [Pubmed]
  10. Drosophila tufted is a gain-of-function allele of the proneural gene amos. Lai, E.C. Genetics (2003) [Pubmed]
  11. Early neurogenesis of the Drosophila brain. Younossi-Hartenstein, A., Nassif, C., Green, P., Hartenstein, V. J. Comp. Neurol. (1996) [Pubmed]
  12. The Enhancer of split and Achaete-Scute complexes of Drosophilids derived from simple ur-complexes preserved in mosquito and honeybee. Schlatter, R., Maier, D. BMC Evol. Biol. (2005) [Pubmed]
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