Disease relevance of Genes, Lethal

• A phosphonate monoester hydrolase from Burkholderia caryophilli PG2982 is useful as a conditional lethal gene in plants [1].

High impact information on Genes, Lethal

• This hypertranscription requires the functions of at least four autosomal male-specific lethal genes (msls) and is under the control of the Sex-lethal (Sxl) gene [2].
• The lethal gene was maintained under control of the lac repressor on a low copy plasmid [3].
• Nine newly established recombinant H-2 haplotypes, which arose from the heterozygous mice that resulted from a cross between common inbred H-2 haplotypes and the aw18 haplotype, allowed us to map the lethal gene to the class III region of the H-2 complex [4].
• Using the steady-state distribution of recessive lethal gene the probability of finding the elevated frequency of Tay-Sachs (TSD) gene among Ashkenazic Jews is computed [5].
• After the precursors divide, a combination of repression by Wingless and activation by Hedgehog induces expression of the proneural gene lethal of scute in the most anterior midline daughter cells of the neighbouring posterior segment [6].

Biological context of Genes, Lethal

• The lethal gene used here is a CaMV 35S-barnase gene with an intron in the coding sequence (barnase-INT); the screenable marker is a pMAS-luciferase gene with an intron in the coding sequence (LUC-int) [7].
• A second chromosome male-specific lethal gene, maleless (mle), in D. melanogaster is described [8].
• Mutagenicity studies with 5-thio-D-glucose. Cytogenetic investigation in mice, and the sex-linked recessive lethal gene test in Drosophila [9].

Associations of Genes, Lethal with chemical compounds

• A bacterial phosphonate monoester hydrolase was evaluated in plants as a conditional lethal gene useful for cell ablation and negative selection [1].
• It places six genes, hook, 1(2) and, and four lethal genes, in a maximum of five bands, 37B10, 11, 12, 13 and perhaps part of the 37C1,2 singlet and localizes six genes, Ddc plus five lethal genes, in a maximum of three bands; probably part of the 37C1,2 singlet plus bands, C3, and C4 [10].
• Dominant lethal gene test of 5-thio-D-glucose in male mice [11].

Gene context of Genes, Lethal

• Mutations in the zygotic lethal gene pha-1 affect a late step during organ development in the nematode C. elegans [12].
• In both species, another gene that lies <350 bp upstream from the nonA transcription starts, and that probably corresponds to the lethal gene l(1)i19, was identified [13].
• Cloning, sequencing and disruption of NGD29 showed that it is a non lethal gene and identical to OCH1 [14].
• The Pim-1 gene was localized 0.6 cM proximal to the tw12 lethal gene, thus placing the Pim-1 gene 5.2 cM distal to the H-2 region in t-haplotypes [15].
• Mouse Oct-3 maps between the tcl12 embryonic lethal gene and the Qa gene in the H-2 complex [16].

References