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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Genes, Lethal

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Disease relevance of Genes, Lethal


High impact information on Genes, Lethal

  • This hypertranscription requires the functions of at least four autosomal male-specific lethal genes (msls) and is under the control of the Sex-lethal (Sxl) gene [2].
  • The lethal gene was maintained under control of the lac repressor on a low copy plasmid [3].
  • Nine newly established recombinant H-2 haplotypes, which arose from the heterozygous mice that resulted from a cross between common inbred H-2 haplotypes and the aw18 haplotype, allowed us to map the lethal gene to the class III region of the H-2 complex [4].
  • Using the steady-state distribution of recessive lethal gene the probability of finding the elevated frequency of Tay-Sachs (TSD) gene among Ashkenazic Jews is computed [5].
  • After the precursors divide, a combination of repression by Wingless and activation by Hedgehog induces expression of the proneural gene lethal of scute in the most anterior midline daughter cells of the neighbouring posterior segment [6].

Biological context of Genes, Lethal


Associations of Genes, Lethal with chemical compounds

  • A bacterial phosphonate monoester hydrolase was evaluated in plants as a conditional lethal gene useful for cell ablation and negative selection [1].
  • It places six genes, hook, 1(2) and, and four lethal genes, in a maximum of five bands, 37B10, 11, 12, 13 and perhaps part of the 37C1,2 singlet and localizes six genes, Ddc plus five lethal genes, in a maximum of three bands; probably part of the 37C1,2 singlet plus bands, C3, and C4 [10].
  • Dominant lethal gene test of 5-thio-D-glucose in male mice [11].

Gene context of Genes, Lethal

  • Mutations in the zygotic lethal gene pha-1 affect a late step during organ development in the nematode C. elegans [12].
  • In both species, another gene that lies <350 bp upstream from the nonA transcription starts, and that probably corresponds to the lethal gene l(1)i19, was identified [13].
  • Cloning, sequencing and disruption of NGD29 showed that it is a non lethal gene and identical to OCH1 [14].
  • The Pim-1 gene was localized 0.6 cM proximal to the tw12 lethal gene, thus placing the Pim-1 gene 5.2 cM distal to the H-2 region in t-haplotypes [15].
  • Mouse Oct-3 maps between the tcl12 embryonic lethal gene and the Qa gene in the H-2 complex [16].


  1. A phosphonate monoester hydrolase from Burkholderia caryophilli PG2982 is useful as a conditional lethal gene in plants. Dotson, S.B., Lanahan, M.B., Smith, A.G., Kishore, G.M. Plant J. (1996) [Pubmed]
  2. Regulation of the sex-specific binding of the maleless dosage compensation protein to the male X chromosome in Drosophila. Gorman, M., Kuroda, M.I., Baker, B.S. Cell (1993) [Pubmed]
  3. Dominant lethal phenotype of a mutation in the -35 recognition region of Escherichia coli sigma 70. Keener, J., Nomura, M. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  4. Lethal deletion of the complement component C4 and steroid 21-hydroxylase genes in the mouse H-2 class III region, caused by meiotic recombination. Shiroishi, T., Sagai, T., Natsuume-Sakai, S., Moriwaki, K. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  5. Elevated frequency of Tay-Sachs disease among Ashkenazic Jews unlikely by genetic drift alone. Chakravarti, A., Chakraborty, R. Am. J. Hum. Genet. (1978) [Pubmed]
  6. Determination of cell fate along the anteroposterior axis of the Drosophila ventral midline. Bossing, T., Brand, A.H. Development (2006) [Pubmed]
  7. A simple method to enrich an Agrobacterium-transformed population for plants containing only T-DNA sequences. Hanson, B., Engler, D., Moy, Y., Newman, B., Ralston, E., Gutterson, N. Plant J. (1999) [Pubmed]
  8. Maleless, a recessive autosomal mutant of Drosophila melanogaster that specifically kills male zygotes. Fukunaga, A., Tanaka, A., Oishi, K. Genetics (1975) [Pubmed]
  9. Mutagenicity studies with 5-thio-D-glucose. Cytogenetic investigation in mice, and the sex-linked recessive lethal gene test in Drosophila. Majumdar, S.K., Buchanan, B., Feinstein, S. J. Hered. (1979) [Pubmed]
  10. The genetics of dopa decarboxylase in Drosophila melanogaster. IV. The genetics and cytology of the 37B10-37D1 region. Wright, T.R., Beermann, W., Marsh, J.L., Bishop, C.P., Steward, R., Black, B.C., Tomsett, A.D., Wright, E.Y. Chromosoma (1981) [Pubmed]
  11. Dominant lethal gene test of 5-thio-D-glucose in male mice. Majumdar, S.K., Ringer, L.D., McFadden, L. J. Hered. (1979) [Pubmed]
  12. Genesis of an organ: molecular analysis of the pha-1 gene. Granato, M., Schnabel, H., Schnabel, R. Development (1994) [Pubmed]
  13. Comparative analysis of the nonA region in Drosophila identifies a highly diverged 5' gene that may constrain nonA promoter evolution. Campesan, S., Chalmers, D., Sandrelli, F., Megighian, A., Peixoto, A.A., Costa, R., Kyriacou, C.P. Genetics (2001) [Pubmed]
  14. Glycoprotein biosynthesis in Saccharomyces cerevisiae: ngd29, an N-glycosylation mutant allelic to och1 having a defect in the initiation of outer chain formation. Lehle, L., Eiden, A., Lehnert, K., Haselbeck, A., Kopetzki, E. FEBS Lett. (1995) [Pubmed]
  15. Mapping of the Pim-1 oncogene in mouse t-haplotypes and its use to define the relative map positions of the tcl loci t0(t6) and tw12 and the marker tf (tufted). Ark, B., Gummere, G., Bennett, D., Artzt, K. Genomics (1991) [Pubmed]
  16. Mouse Oct-3 maps between the tcl12 embryonic lethal gene and the Qa gene in the H-2 complex. Uehara, H. Immunogenetics (1991) [Pubmed]
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