The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Gene Review

Pig1  -  Pre-intermoult gene 1

Drosophila melanogaster

Synonyms: CG10790, Dmel\CG10790, EG:96G10.1, Gland-specific protein, Pig-1, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on Pig1

  • In this paper, we show that three adjacent elements located within the short region between these genes can account for the switch from Pig-1 to Sgs-4 expression [1].
  • The Pre-intermoult gene-1 (Pig-1) of Drosophila melanogaster maps on the X chromosome, at polytene bands 3C11-12, and is nested within the 79 kb intron of the dunce gene [2].
  • We also report that the level of Pig-1 transcript is nearly fourfold reduced in a variant strain carrying a deletion within the Pig-1 upstream sequence, thus identifying a regulatory element required for high level gene expression [2].
  • The corresponding gene is active only in larval salivary glands and, therefore, is named gland specific gene, gsg [3].
  • Point mutations that disrupt this site had no significant effect on activation of the Sgs-4 promoter in constructs lacking the Pig-1 promoter [4].

Biological context of Pig1


Anatomical context of Pig1


  1. A transcriptional switch between the Pig-1 and Sgs-4 genes of Drosophila melanogaster. Mougneau, E., von Seggern, D., Fowler, T., Rosenblatt, J., Jongens, T., Rogers, B., Gietzen, D., Beckendorf, S.K. Mol. Cell. Biol. (1993) [Pubmed]
  2. Molecular organization of the Drosophila melanogaster Pig-1 gene. Furia, M., Digilio, F.A., Artiaco, D., D'Avino, P.P., Cavaliere, D., Polito, L.C. Chromosoma (1991) [Pubmed]
  3. Upstream sequences of dosage-compensated and non-compensated alleles of the larval secretion protein gene Sgs-4 in Drosophila. Hofmann, A., Korge, G. Chromosoma (1987) [Pubmed]
  4. The transcriptional switch between the Drosophila genes Pig-1 and Sgs-4 depends on a SEBP1 binding site within a shared enhancer region. Hofmann, A., Lehmann, M. Mol. Gen. Genet. (1998) [Pubmed]
WikiGenes - Universities