High impact information on swa

• The maternal effect gene swallow ( swa) of Drosophila is required for bicoid and htsN4 mRNA localization during oogenesis [1].
• We have examined the cytoskeleton in swa mutant oocytes and embryos by immunocytochemistry and confocal microscopy [1].
• In swa syncytial blastoderm embryos, the abnormal actin cytoskeleton is associated with defects in nuclear distribution, migration and cleavage [1].
• Several sww mutations also result in oskar RNA localization defects, consistent with a global role for sww in cytoskeletal regulation or organization [2].
• In several sww mutants, a portion of the bcd mRNA population becomes concentrated at the posterior pole of the oocyte during late oogenesis [2].

Biological context of swa

• We initiated a detailed characterization of the phenotypes associated with each of eight sww alleles as a means of investigating the role of sww in oogenic patterning [2].

Analytical, diagnostic and therapeutic context of swa

• RNA localization defects in various sww mutants were examined by radioactive in situ hybridization to paraffin sections [2].

References