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Gene Review

nonC  -  no-on-and-no-off transient C

Drosophila melanogaster

Synonyms: CG32743, CG4549, CG4555, Dmel\CG32743, SMG1, ...
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High impact information on Smg1


Biological context of Smg1

  • By contrast, we find that the PI3K-related kinase Smg1 potentiates but is not required for NMD or for viability, implying that the Upf1 phosphorylation cycle that is required for mammalian and Caenorhabditis elegans NMD has a more limited role during Drosophila development [3].


  1. Smg1 nonsense mutations do not abolish nonsense-mediated mRNA decay in Drosophila melanogaster. Chen, Z., Smith, K.R., Batterham, P., Robin, C. Genetics (2005) [Pubmed]
  2. Positional cloning of a cyromazine resistance gene in Drosophila melanogaster. Chen, Z., Robin, C., Damiano, J., Lydall, J., Lumb, C., Smith, K., Blasetti, A., Daborn, P.J., Heckel, D., McKenzie, J.A., Batterham, P. Insect Mol. Biol. (2006) [Pubmed]
  3. Functions of the nonsense-mediated mRNA decay pathway in Drosophila development. Metzstein, M.M., Krasnow, M.A. PLoS Genet. (2006) [Pubmed]
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