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Gene Review:

nonC - no-on-and-no-off transient C

Drosophila melanogaster

Synonyms: CG32743, CG4549, CG4555, Dmel\CG32743, SMG1, ...

Metzstein, M.M. et al., Chen, Z. et al., Chen, Z. et al.

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High impact information on Smg1

Smg1 nonsense mutations do not abolish nonsense-mediated mRNA decay in Drosophila melanogaster [1].
In mammals Smg1 phosphorylates P53 in response to DNA damage [2].
RNAi experiments confirm that cyromazine resistance can be achieved by knocking down CG32743 [2].
Mapping and molecular analyses show that photoshop mutations are loss-of-function mutations in the Drosophila homologs of NMD genes Upf1, Upf2, and Smg1 [3].

Biological context of Smg1

By contrast, we find that the PI3K-related kinase Smg1 potentiates but is not required for NMD or for viability, implying that the Upf1 phosphorylation cycle that is required for mammalian and Caenorhabditis elegans NMD has a more limited role during Drosophila development [3].

References

Smg1 nonsense mutations do not abolish nonsense-mediated mRNA decay in Drosophila melanogaster. Chen, Z., Smith, K.R., Batterham, P., Robin, C. Genetics (2005) [Pubmed]
Positional cloning of a cyromazine resistance gene in Drosophila melanogaster. Chen, Z., Robin, C., Damiano, J., Lydall, J., Lumb, C., Smith, K., Blasetti, A., Daborn, P.J., Heckel, D., McKenzie, J.A., Batterham, P. Insect Mol. Biol. (2006) [Pubmed]
Functions of the nonsense-mediated mRNA decay pathway in Drosophila development. Metzstein, M.M., Krasnow, M.A. PLoS Genet. (2006) [Pubmed]

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