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Gene Review

p115  -  CG1422 gene product from transcript CG1422-RB

Drosophila melanogaster

Synonyms: CG1422, Dmel\CG1422, dp115, l(1)G0306
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High impact information on p115

  • Here, we describe that depletion of the Drosophila homologue of p115 (dp115) by RNA interference in Drosophila S2 cells led to important morphological changes in the Golgi stack morphology and the transitional ER (tER) organization [1].
  • The de novo model for Golgi stack biogenesis predicts that membrane exiting the ER at transitional ER (tER) sites contains and recruits all the necessary molecules to form a Golgi stack, including the Golgi matrix proteins, p115, GM130, and GRASP65/55 [2].


  1. A novel role for dp115 in the organization of tER sites in Drosophila. Kondylis, V., Rabouille, C. J. Cell Biol. (2003) [Pubmed]
  2. dGRASP localization and function in the early exocytic pathway in Drosophila S2 cells. Kondylis, V., Spoorendonk, K.M., Rabouille, C. Mol. Biol. Cell (2005) [Pubmed]
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