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Gene Review

USO1  -  USO1 vesicle transport factor

Homo sapiens

Synonyms: General vesicular transport factor p115, P115, Protein USO1 homolog, TAP, Transcytosis-associated protein, ...
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Disease relevance of VDP

  • These results suggest that a small amount of VDP remains associated with the infecting vRNA, and recommend a model which involves a subviral particle such as a functional molecule probably involved in the initial steps of poliovirus replication [1].
  • Sixty-two adult patients with acute lymphoblastic leukemia (ALL) were treated with an induction regimen including vincristine, daunorubicin and prednisone (VDP) followed by CNS prophylaxis [2].
  • A previous study found an association between ADHD and two polymorphisms in the 3' untranslated region (UTR) of SNAP-25, a gene encoding a synaptic vesicle docking protein known to play a role in the hyperactivity observed in the Coloboma mouse strain [3].
  • The p12 structural component of Gardner FeSV P115, but not Snyder-Theilen FeSV 115, corresponds to feline leukemia virus subgroup A with respect to immunological type specificity, a finding consistent with the independent origin of these viruses [4].
  • The majority of sera tested from humans with diagnosed pneumocystosis reacted strongly with the P115 proteins [5].

High impact information on VDP


Biological context of VDP


Anatomical context of VDP

  • P115 is phosphorylated on serine 942, and this modification appears to control p115 association with membranes [11].
  • A monoclonal antibody raised against cysts recognized all six variants and reacted with epitopes that were located in the cell wall, thereby indicating that P115 is an immunoreactive surface component [5].
  • HPC-1/syntaxin, an axonal membrane protein, was classified as an anchoring protein, not as the vesicle docking protein, because electron microscopic study using cryoimmunogold technique revealed that HPC-1 distributed over the entire axonal membrane, where the synaptic vesicles were not 'docked' to the membrane [12].

Associations of VDP with chemical compounds

  • The accumulation of VDP in the heavy fraction (HF) paralleled polio-specific protein synthesis, and it was prevented by cycloheximide [1].
  • The rest of the labeled VDP was found mostly associated to a heavy subviral ribonucleoprotein (H-vRNP) compatible with a ribosome-RNA complex, due to its ssRNA content, its sedimentation behavior and buoyant density (1.54 g/cc), and its EDTA lability [1].
  • In summary, our studies have shown clear advantages of the SI-VDP setup for the nitroxide-mediated polymerization scheme in controlling synthesis of end-grafted homo- and copolymer thin films [13].
  • Through the SI-VDP, end-grafted polymer films of polystyrene (PSt), poly(acrylic acid) (PAAc), poly(N-(2-hydroxypropyl) methacrylamide) (PHPMA), and poly(N-isopropylacrylamide) (PNIPAAm) with 10-200 nm thicknesses were fabricated [13].

Other interactions of VDP

  • Novel functional polydipyrrole- and polydicarbazole nanorods have been AAO template-synthesized from COOH-dipyrrole/-dicarbazole monomers using Vapor Deposition and Liquid Phase Polymerizations (VDP and LPP) [14].
  • GLP is 50% homologous to other Golgin-related proteins including the vesicle docking protein GM130 [15].

Analytical, diagnostic and therapeutic context of VDP


  1. Poliovirion-derived capsid proteins in subviral ribonucleoprotein complexes. Cantero-Aguilar, L., Sanchez-Trujillo, A., Fernandez-Tomas, C. Virology (1987) [Pubmed]
  2. Adult acute lymphoblastic leukemia. Response to therapy according to presenting features in 62 patients. Lazzarino, M., Morra, E., Alessandrino, E.P., Canevari, A., Salvaneschi, L., Castelli, G., Brusamolino, E., Pagnucco, G., Isernia, P., Orlandi, E., Zei, G., Bernasconi, C. European journal of cancer & clinical oncology. (1982) [Pubmed]
  3. Biased paternal transmission of SNAP-25 risk alleles in attention-deficit hyperactivity disorder. Kustanovich, V., Merriman, B., McGough, J., McCracken, J.T., Smalley, S.L., Nelson, S.F. Mol. Psychiatry (2003) [Pubmed]
  4. Translational products encoded by newly acquired sequences of independently derived feline sarcoma virus isolates are structurally related. Van de Ven, W.J., Khan, A.S., Reynolds, F.H., Mason, K.T., Stephenson, J.R. J. Virol. (1980) [Pubmed]
  5. Glycoproteins composed of major surface immunodeterminants of Pneumocystis carinii. Tanabe, K., Takasaki, S., Watanabe, J., Kobata, A., Egawa, K., Nakamura, Y. Infect. Immun. (1989) [Pubmed]
  6. The vesicle docking protein p115 binds GM130, a cis-Golgi matrix protein, in a mitotically regulated manner. Nakamura, N., Lowe, M., Levine, T.P., Rabouille, C., Warren, G. Cell (1997) [Pubmed]
  7. Phosphorylation of the vesicle docking protein p115 regulates its association with the Golgi membrane. Sohda, M., Misumi, Y., Yano, A., Takami, N., Ikehara, Y. J. Biol. Chem. (1998) [Pubmed]
  8. Binding of the vesicle docking protein p115 to Golgi membranes is inhibited under mitotic conditions. Levine, T.P., Rabouille, C., Kieckbusch, R.H., Warren, G. J. Biol. Chem. (1996) [Pubmed]
  9. Identification and characterization of a novel Golgi protein, golgin-67. Jakymiw, A., Raharjo, E., Rattner, J.B., Eystathioy, T., Chan, E.K., Fujita, D.J. J. Biol. Chem. (2000) [Pubmed]
  10. Plant 115-kDa actin-filament bundling protein, P-115-ABP, is a homologue of plant villin and is widely distributed in cells. Yokota, E., Vidali, L., Tominaga, M., Tahara, H., Orii, H., Morizane, Y., Hepler, P.K., Shimmen, T. Plant Cell Physiol. (2003) [Pubmed]
  11. Membrane targeting of p115 phosphorylation mutants and their effects on Golgi integrity and secretory traffic. Brandon, E., Gao, Y., Garcia-Mata, R., Alvarez, C., Sztul, E. Eur. J. Cell Biol. (2003) [Pubmed]
  12. Exocytosis relating proteins in the nervous system. Yamaguchi, K., Akagawa, K. Neurosci. Res. (1994) [Pubmed]
  13. Preparation of end-grafted polymer brushes by nitroxide-mediated free radical polymerization of vaporized vinyl monomers. Li, J., Chen, X., Chang, Y.C. Langmuir : the ACS journal of surfaces and colloids. (2005) [Pubmed]
  14. Polydipyrrole- and polydicarbazole-nanorods as new nanosized supports for DNA hybridization. Lellouche, J.P., Govindaraji, S., Joseph, A., Jang, J., Lee, K.J. Chem. Commun. (Camb.) (2005) [Pubmed]
  15. Cloning and characterization of a Golgin-related gene from the large-scale polymorphism linked to the PML gene. Gilles, F., Goy, A., Remache, Y., Manova, K., Zelenetz, A.D. Genomics (2000) [Pubmed]
  16. Stem fracture in the VDP prosthesis. Simon, J.P. Journal of orthopaedic trauma. (1996) [Pubmed]
  17. An audit on the placement and replacement of restorations in a general dental practice. Frost, P.M. Primary dental care : journal of the Faculty of General Dental Practitioners (UK). (2002) [Pubmed]
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