Disease relevance of VDP

• These results suggest that a small amount of VDP remains associated with the infecting vRNA, and recommend a model which involves a subviral particle such as a functional molecule probably involved in the initial steps of poliovirus replication [1].
• Sixty-two adult patients with acute lymphoblastic leukemia (ALL) were treated with an induction regimen including vincristine, daunorubicin and prednisone (VDP) followed by CNS prophylaxis [2].
• A previous study found an association between ADHD and two polymorphisms in the 3' untranslated region (UTR) of SNAP-25, a gene encoding a synaptic vesicle docking protein known to play a role in the hyperactivity observed in the Coloboma mouse strain [3].
• The p12 structural component of Gardner FeSV P115, but not Snyder-Theilen FeSV 115, corresponds to feline leukemia virus subgroup A with respect to immunological type specificity, a finding consistent with the independent origin of these viruses [4].
• The majority of sera tested from humans with diagnosed pneumocystosis reacted strongly with the P115 proteins [5].

High impact information on VDP

• The vesicle docking protein p115 binds GM130, a cis-Golgi matrix protein, in a mitotically regulated manner [6].
• Phosphorylation of the vesicle docking protein p115 regulates its association with the Golgi membrane [7].
• The vesicle docking protein p115 was found to be phosphorylated in a cell cycle-specific manner; it was found phosphorylated in interphase but not in mitotic cells [7].
• Binding of the vesicle docking protein p115 to Golgi membranes is inhibited under mitotic conditions [8].
• Tryptic peptide analysis revealed five methionine-containing peptides specific to the nonstructural portion of Gardner FeSV 115, three of which were also represented in Snyder-Theilen FeSV P115, three of which were also represented in Snyder-Theilen FeSV P115 [4].

Biological context of VDP

• It has sequence homologies to other Golgi proteins, including the coatamer complex I vesicle docking protein, GM130 [9].
• Deglycosylated P115 migrates primarily as a single more acidic protein in two-dimensional gels, suggesting that the isoelectric variants may be due primarily to differences in glycosylation [5].
• Microinjection of the antiserum against P-115-ABP into living root hair cells caused the disappearance of transvaculor strands and alteration of the route of cytoplasmic streaming [10].

Anatomical context of VDP

• P115 is phosphorylated on serine 942, and this modification appears to control p115 association with membranes [11].
• A monoclonal antibody raised against cysts recognized all six variants and reacted with epitopes that were located in the cell wall, thereby indicating that P115 is an immunoreactive surface component [5].
• HPC-1/syntaxin, an axonal membrane protein, was classified as an anchoring protein, not as the vesicle docking protein, because electron microscopic study using cryoimmunogold technique revealed that HPC-1 distributed over the entire axonal membrane, where the synaptic vesicles were not 'docked' to the membrane [12].

Associations of VDP with chemical compounds

• The accumulation of VDP in the heavy fraction (HF) paralleled polio-specific protein synthesis, and it was prevented by cycloheximide [1].
• The rest of the labeled VDP was found mostly associated to a heavy subviral ribonucleoprotein (H-vRNP) compatible with a ribosome-RNA complex, due to its ssRNA content, its sedimentation behavior and buoyant density (1.54 g/cc), and its EDTA lability [1].
• In summary, our studies have shown clear advantages of the SI-VDP setup for the nitroxide-mediated polymerization scheme in controlling synthesis of end-grafted homo- and copolymer thin films [13].
• Through the SI-VDP, end-grafted polymer films of polystyrene (PSt), poly(acrylic acid) (PAAc), poly(N-(2-hydroxypropyl) methacrylamide) (PHPMA), and poly(N-isopropylacrylamide) (PNIPAAm) with 10-200 nm thicknesses were fabricated [13].

Other interactions of VDP

• Novel functional polydipyrrole- and polydicarbazole nanorods have been AAO template-synthesized from COOH-dipyrrole/-dicarbazole monomers using Vapor Deposition and Liquid Phase Polymerizations (VDP and LPP) [14].
• GLP is 50% homologous to other Golgin-related proteins including the vesicle docking protein GM130 [15].

Analytical, diagnostic and therapeutic context of VDP

• Stem fracture in the VDP prosthesis [16].
• The author's results will be compared with a VDP study and the multicentre study [17].

References