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Gene Review

omp1  -  outer membrane protein 1

Anaplasma marginale str. St. Maries

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Disease relevance of omp1

  • Interestingly, the 5' structure of this A. marginale msp2 locus is conserved in the omp1 gene locus of Ehrlichia chaffeensis and p30 gene locus of E. canis despite marked divergence between genera in the structure of the 3' region of the loci [1].

High impact information on omp1

  • The msp2 gene in the A. phagocytophilum strain HZ genome was a single-copy gene and was located downstream of two Ehrlichia chaffeensis omp-1 homologs and a decarboxylase gene (ubiD) [2].
  • Synonymous and nonsynonymous exchanges were infrequent in omp1 and rare in opag1 and opag2 among the six strains without strong bias for either type of exchange (neutral mutations) [1].

Biological context of omp1


  1. Characterization of the Anaplasma marginale msp2 locus and its synteny with the omp1/p30 loci of Ehrlichia chaffeensis and E. canis. Löhr, C.V., Brayton, K.A., Barbet, A.F., Palmer, G.H. Gene (2004) [Pubmed]
  2. Anaplasma phagocytophilum has a functional msp2 gene that is distinct from p44. Lin, Q., Rikihisa, Y., Felek, S., Wang, X., Massung, R.F., Woldehiwet, Z. Infect. Immun. (2004) [Pubmed]
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