Disease relevance of fs(1)h

• Latent nuclear antigen of Kaposi's sarcoma-associated herpesvirus interacts with RING3, a homolog of the Drosophila female sterile homeotic (fsh) gene [1].

High impact information on fs(1)h

• Here we report that LANA interacts with RING3, a nuclear protein and member of the Drosophila fsh (female sterile homeotic) family of proteins, some of which have previously been implicated in controlling gene expression [1].
• The fsh locus interacts synergistically with loci such as Ubx and trx in the production of homeotic transformations [2].
• The Drosophila fsh locus, a maternal effect homeotic gene, encodes apparent membrane proteins [2].
• Hypodosage of this region is mainly effective at the level of the maternal genotype, and the effect is probably due to hypodosage of the wild-type allele of the gene fs(1)h. Df(3)red has an effect that is mainly, if not exclusively, zygotic, probably due to hypodosage of the wild-type allele of Rg-bx [3].
• RING3 and D26362 are also related to the Drosophila developmental gene fsh [4].

Other interactions of fs(1)h

• We suggest that the expression of fsh proteins in the membrane of the embryo is required for proper functioning of genes such as Ubx in the specification of segmental identity [2].

References