Gene Review:
trx - trithorax
Drosophila melanogaster
Synonyms:
4720, 4733, CG8651, DMTRXIII, Dmel\CG8651, ...
- The trithorax gene, a trans-acting regulator of the bithorax complex in Drosophila, encodes a protein with zinc-binding domains. Mazo, A.M., Huang, D.H., Mozer, B.A., Dawid, I.B. Proc. Natl. Acad. Sci. U.S.A. (1990)
- MLL5, a homolog of Drosophila trithorax located within a segment of chromosome band 7q22 implicated in myeloid leukemia. Emerling, B.M., Bonifas, J., Kratz, C.P., Donovan, S., Taylor, B.R., Green, E.D., Le Beau, M.M., Shannon, K.M. Oncogene (2002)
- Trithorax is required to maintain engrailed expression in a subset of engrailed-expressing cells. Breen, T.R., Chinwalla, V., Harte, P.J. Mech. Dev. (1995)
- Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias. Tkachuk, D.C., Kohler, S., Cleary, M.L. Cell (1992)
- Polycomb and trithorax group proteins mediate the function of a chromatin insulator. Gerasimova, T.I., Corces, V.G. Cell (1998)
- Trithorax and dCBP acting in a complex to maintain expression of a homeotic gene. Petruk, S., Sedkov, Y., Smith, S., Tillib, S., Kraevski, V., Nakamura, T., Canaani, E., Croce, C.M., Mazo, A. Science (2001)
- A homeotic mutation in the trithorax SET domain impedes histone binding. Katsani, K.R., Arredondo, J.J., Kal, A.J., Verrijzer, C.P. Genes Dev. (2001)
- Molecular characterization of the trithorax gene, a positive regulator of homeotic gene expression in Drosophila. Breen, T.R., Harte, P.J. Mech. Dev. (1991)
- The Drosophila trithorax gene encodes a chromosomal protein and directly regulates the region-specific homeotic gene fork head. Kuzin, B., Tillib, S., Sedkov, Y., Mizrokhi, L., Mazo, A. Genes Dev. (1994)
- Functional reconstruction of trans regulation of the Ultrabithorax promoter by the products of two antagonistic genes, trithorax and Polycomb. Chang, Y.L., King, B.O., O'Connor, M., Mazo, A., Huang, D.H. Mol. Cell. Biol. (1995)
- The bithorax complex is regulated by trithorax earlier during Drosophila embryogenesis than is the Antennapedia complex, correlating with a bithorax-like expression pattern of distinct early trithorax transcripts. Sedkov, Y., Tillib, S., Mizrokhi, L., Mazo, A. Development (1994)
- Conservation of structure and expression of the trithorax gene between Drosophila virilis and Drosophila melanogaster. Tillib, S., Sedkov, Y., Mizrokhi, L., Mazo, A. Mech. Dev. (1995)
- Tissue-specific TAFs counteract Polycomb to turn on terminal differentiation. Chen, X., Hiller, M., Sancak, Y., Fuller, M.T. Science (2005)
- The Drosophila trithorax proteins contain a novel variant of the nuclear receptor type DNA binding domain and an ancient conserved motif found in other chromosomal proteins. Stassen, M.J., Bailey, D., Nelson, S., Chinwalla, V., Harte, P.J. Mech. Dev. (1995)
- Trithorax interacts with type 1 serine/threonine protein phosphatase in Drosophila. Rudenko, A., Bennett, D., Alphey, L. EMBO Rep. (2003)
- ASH1, a Drosophila trithorax group protein, is required for methylation of lysine 4 residues on histone H3. Byrd, K.N., Shearn, A. Proc. Natl. Acad. Sci. U.S.A. (2003)
- DEAF-1, a novel protein that binds an essential region in a Deformed response element. Gross, C.T., McGinnis, W. EMBO J. (1996)
- The direct interaction between ASH2, a Drosophila trithorax group protein, and SKTL, a nuclear phosphatidylinositol 4-phosphate 5-kinase, implies a role for phosphatidylinositol 4,5-bisphosphate in maintaining transcriptionally active chromatin. Cheng, M.K., Shearn, A. Genetics (2004)
- PP1beta9C interacts with Trithorax in Drosophila wing development. Rudenko, A., Bennett, D., Alphey, L. Dev. Dyn. (2004)
- The Drosophila trithorax group proteins BRM, ASH1 and ASH2 are subunits of distinct protein complexes. Papoulas, O., Beek, S.J., Moseley, S.L., McCallum, C.M., Sarte, M., Shearn, A., Tamkun, J.W. Development (1998)
- The Drosophila trithorax protein binds to specific chromosomal sites and is co-localized with Polycomb at many sites. Chinwalla, V., Jane, E.P., Harte, P.J. EMBO J. (1995)
- Characterization of the extended Myb-like DNA-binding domain of trithorax group protein Zeste. Mohrmann, L., Kal, A.J., Verrijzer, C.P. J. Biol. Chem. (2002)
- Binding of trithorax and Polycomb proteins to the bithorax complex: dynamic changes during early Drosophila embryogenesis. Orlando, V., Jane, E.P., Chinwalla, V., Harte, P.J., Paro, R. EMBO J. (1998)
- Trithorax regulates multiple homeotic genes in the bithorax and Antennapedia complexes and exerts different tissue-specific, parasegment-specific and promoter-specific effects on each. Breen, T.R., Harte, P.J. Development (1993)
- Trithorax- and Polycomb-group response elements within an Ultrabithorax transcription maintenance unit consist of closely situated but separable sequences. Tillib, S., Petruk, S., Sedkov, Y., Kuzin, A., Fujioka, M., Goto, T., Mazo, A. Mol. Cell. Biol. (1999)
- Transcriptional network controlled by the trithorax-group gene ash2 in Drosophila melanogaster. Beltran, S., Blanco, E., Serras, F., Pérez-Villamil, B., Guigó, R., Artavanis-Tsakonas, S., Corominas, M. Proc. Natl. Acad. Sci. U.S.A. (2003)
- Isolation of a novel retinoic acid-responsive gene by selection of genomic fragments derived from CpG-island-enriched DNA. Shago, M., Giguére, V. Mol. Cell. Biol. (1996)