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Gene Review

Smox  -  Smad on X

Drosophila melanogaster

Synonyms: CG2262, DSMAD2, DSmad2, Dmel\CG2262, SMAD2, ...
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Disease relevance of Smox


High impact information on Smox

  • Loss of dril1 inhibits the response of animal caps to activin and secondary axis induction by smad2 [2].
  • Here, we report the first identification of a novel Drosophila R-SMAD, which we have named Smox for Smad on X. We have localized the Smox gene to a specific interval on the X chromosome and shown that Smox is transcribed throughout development [3].

Other interactions of Smox

  • RESULTS: Here we report the identification of dSmad2, a new Drosophila Smad which is most related to the activin/TGFbeta-pathway Smads, Smad2 and Smad3 [4].


  1. Intracellular signaling of the TGF-beta superfamily by Smad proteins. Kawabata, M., Imamura, T., Inoue, H., Hanai, J., Nishihara, A., Hanyu, A., Takase, M., Ishidou, Y., Udagawa, Y., Oeda, E., Goto, D., Yagi, K., Kato, M., Miyazono, K. Ann. N. Y. Acad. Sci. (1999) [Pubmed]
  2. The ARID domain protein dril1 is necessary for TGF(beta) signaling in Xenopus embryos. Callery, E.M., Smith, J.C., Thomsen, G.H. Dev. Biol. (2005) [Pubmed]
  3. Identification of a novel Drosophila SMAD on the X chromosome. Henderson, K.D., Andrew, D.J. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
  4. Drosophila dSmad2 and Atr-I transmit activin/TGFbeta signals. Das, P., Inoue, H., Baker, J.C., Beppu, H., Kawabata, M., Harland, R.M., Miyazono, K., Padgett, R.W. Genes Cells (1999) [Pubmed]
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