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Gene Review:

Smox - Smad on X

Drosophila melanogaster

Synonyms: CG2262, DSMAD2, DSmad2, Dmel\CG2262, SMAD2, ...

Henderson, K.D. et al., Das, P. et al., Callery, E.M. et al., Kawabata, M. et al.

Kawabata, Imamura, Inoue, Hanai, Nishihara, Hanyu, Takase, Ishidou, Udagawa, Oeda, Goto, Yagi, Kato, Miyazono,

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Disease relevance of Smox

A missense mutation of Smad2 identified in colorectal and lung cancers was introduced to Smad3 [1].

High impact information on Smox

Loss of dril1 inhibits the response of animal caps to activin and secondary axis induction by smad2 [2].
Here, we report the first identification of a novel Drosophila R-SMAD, which we have named Smox for Smad on X. We have localized the Smox gene to a specific interval on the X chromosome and shown that Smox is transcribed throughout development [3].

Other interactions of Smox

RESULTS: Here we report the identification of dSmad2, a new Drosophila Smad which is most related to the activin/TGFbeta-pathway Smads, Smad2 and Smad3 [4].

References

Intracellular signaling of the TGF-beta superfamily by Smad proteins. Kawabata, M., Imamura, T., Inoue, H., Hanai, J., Nishihara, A., Hanyu, A., Takase, M., Ishidou, Y., Udagawa, Y., Oeda, E., Goto, D., Yagi, K., Kato, M., Miyazono, K. Ann. N. Y. Acad. Sci. (1999) [Pubmed]
The ARID domain protein dril1 is necessary for TGF(beta) signaling in Xenopus embryos. Callery, E.M., Smith, J.C., Thomsen, G.H. Dev. Biol. (2005) [Pubmed]
Identification of a novel Drosophila SMAD on the X chromosome. Henderson, K.D., Andrew, D.J. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
Drosophila dSmad2 and Atr-I transmit activin/TGFbeta signals. Das, P., Inoue, H., Baker, J.C., Beppu, H., Kawabata, M., Harland, R.M., Miyazono, K., Padgett, R.W. Genes Cells (1999) [Pubmed]

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AgaP_AGAP009777	Anopheles gambiae str. PEST
SMAD3	Bos taurus
SMAD3	Canis lupus familiaris
smad3b	Danio rerio
SMAD3	Gallus gallus
SMAD3	Homo sapiens
SMAD3	Macaca mulatta
Smad3	Mus musculus
SMAD3	Pan troglodytes
Smad3	Rattus norvegicus
smad3	Xenopus (Silurana) tropicalis

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