Gene Review:
Smad3 - SMAD family member 3
Mus musculus
Synonyms:
AU022421, MAD homolog 3, Mad3, Madh3, Mothers against DPP homolog 3, ...
Berho,
Roberts,
Kucherlapati,
Bottinger,
Pereria-Simon,
Weinstein,
Piek,
Bernard,
Deng,
Elliot,
Goumans,
Striker,
Escalante-Alcalde,
Heyer,
Xia,
Stewart,
Ju,
Mummery,
Espinosa-Heidmann,
Karl,
- Smad3 mutant mice develop metastatic colorectal cancer. Zhu, Y., Richardson, J.A., Parada, L.F., Graff, J.M. Cell (1998)
- Smad3 regulates senescence and malignant conversion in a mouse multistage skin carcinogenesis model. Vijayachandra, K., Lee, J., Glick, A.B. Cancer Res. (2003)
- Smad3 null mice develop airspace enlargement and are resistant to TGF-beta-mediated pulmonary fibrosis. Bonniaud, P., Kolb, M., Galt, T., Robertson, J., Robbins, C., Stampfli, M., Lavery, C., Margetts, P.J., Roberts, A.B., Gauldie, J. J. Immunol. (2004)
- Mice exclusively expressing the short isoform of Smad2 develop normally and are viable and fertile. Dunn, N.R., Koonce, C.H., Anderson, D.C., Islam, A., Bikoff, E.K., Robertson, E.J. Genes Dev. (2005)
- Cell fate decisions within the mouse organizer are governed by graded Nodal signals. Vincent, S.D., Dunn, N.R., Hayashi, S., Norris, D.P., Robertson, E.J. Genes Dev. (2003)
- TGF-beta inhibits muscle differentiation through functional repression of myogenic transcription factors by Smad3. Liu, D., Black, B.L., Derynck, R. Genes Dev. (2001)
- Pro- and antiinflammatory cytokine signaling: reciprocal antagonism regulates interferon-gamma production by human natural killer cells. Yu, J., Wei, M., Becknell, B., Trotta, R., Liu, S., Boyd, Z., Jaung, M.S., Blaser, B.W., Sun, J., Benson, D.M., Mao, H., Yokohama, A., Bhatt, D., Shen, L., Davuluri, R., Weinstein, M., Marcucci, G., Caligiuri, M.A. Immunity (2006)
- Targeted disruption of TGF-beta1/Smad3 signaling protects against renal tubulointerstitial fibrosis induced by unilateral ureteral obstruction. Sato, M., Muragaki, Y., Saika, S., Roberts, A.B., Ooshima, A. J. Clin. Invest. (2003)
- Smad3 deficiency attenuates renal fibrosis, inflammation,and apoptosis after unilateral ureteral obstruction. Inazaki, K., Kanamaru, Y., Kojima, Y., Sueyoshi, N., Okumura, K., Kaneko, K., Yamashiro, Y., Ogawa, H., Nakao, A. Kidney Int. (2004)
- Essential role of Smad3 in angiotensin II-induced vascular fibrosis. Wang, W., Huang, X.R., Canlas, E., Oka, K., Truong, L.D., Deng, C., Bhowmick, N.A., Ju, W., Bottinger, E.P., Lan, H.Y. Circ. Res. (2006)
- Targeted disruption of TGF-beta/Smad3 signaling modulates skin fibrosis in a mouse model of scleroderma. Lakos, G., Takagawa, S., Chen, S.J., Ferreira, A.M., Han, G., Masuda, K., Wang, X.J., DiPietro, L.A., Varga, J. Am. J. Pathol. (2004)
- Reduction of Smad3 accelerates re-epithelialization in a murine model of colitis. Tokumasa, A., Katsuno, T., Tanaga, T.S., Yokote, K., Saito, Y., Suzuki, Y. Biochem. Biophys. Res. Commun. (2004)
- Smad3 as a mediator of the fibrotic response. Flanders, K.C. International journal of experimental pathology. (2004)
- SMAD3 regulates gonadal tumorigenesis. Li, Q., Graff, J.M., O'Connor, A.E., Loveland, K.L., Matzuk, M.M. Mol. Endocrinol. (2007)
- Roles of autocrine TGF-beta receptor and Smad signaling in adipocyte differentiation. Choy, L., Skillington, J., Derynck, R. J. Cell Biol. (2000)
- Functional characterization of transforming growth factor beta signaling in Smad2- and Smad3-deficient fibroblasts. Piek, E., Ju, W.J., Heyer, J., Escalante-Alcalde, D., Stewart, C.L., Weinstein, M., Deng, C., Kucherlapati, R., Bottinger, E.P., Roberts, A.B. J. Biol. Chem. (2001)
- Loss of Smad3 modulates wound healing. Ashcroft, G.S., Roberts, A.B. Cytokine Growth Factor Rev. (2000)
- Orphan Nuclear Receptor Small Heterodimer Partner Inhibits Transforming Growth Factor-beta Signaling by Repressing SMAD3 Transactivation. Suh, J.H., Huang, J., Park, Y.Y., Seong, H.A., Kim, D., Shong, M., Ha, H., Lee, I.K., Lee, K., Wang, L., Choi, H.S. J. Biol. Chem. (2006)
- Deficient Smad7 expression: a putative molecular defect in scleroderma. Dong, C., Zhu, S., Wang, T., Yoon, W., Li, Z., Alvarez, R.J., ten Dijke, P., White, B., Wigley, F.M., Goldschmidt-Clermont, P.J. Proc. Natl. Acad. Sci. U.S.A. (2002)
- Formation of the definitive endoderm in mouse is a Smad2-dependent process. Tremblay, K.D., Hoodless, P.A., Bikoff, E.K., Robertson, E.J. Development (2000)
- Hypoxia inhibition of adipocytogenesis in human bone marrow stromal cells requires transforming growth factor-beta/Smad3 signaling. Zhou, S., Lechpammer, S., Greenberger, J.S., Glowacki, J. J. Biol. Chem. (2005)
- Smad3-deficient chondrocytes have enhanced BMP signaling and accelerated differentiation. Li, T.F., Darowish, M., Zuscik, M.J., Chen, D., Schwarz, E.M., Rosier, R.N., Drissi, H., O'Keefe, R.J. J. Bone Miner. Res. (2006)
- Transforming growth factor beta enhances the glucocorticoid response of the mouse mammary tumor virus promoter through Smad and GA-binding proteins. Aurrekoetxea-Hernández, K., Buetti, E. J. Virol. (2004)
- Activations of ERK1/2 and JNK by transforming growth factor beta negatively regulate Smad3-induced alkaline phosphatase activity and mineralization in mouse osteoblastic cells. Sowa, H., Kaji, H., Yamaguchi, T., Sugimoto, T., Chihara, K. J. Biol. Chem. (2002)
- Smoking Induces Glomerulosclerosis in Aging Estrogen-Deficient Mice through Cross-Talk between TGF-beta1 and IGF-I Signaling Pathways. Elliot, S.J., Karl, M., Berho, M., Xia, X., Pereria-Simon, S., Espinosa-Heidmann, D., Striker, G.E. J. Am. Soc. Nephrol. (2006)
- Parathyroid hormone-Smad3 axis exerts anti-apoptotic action and augments anabolic action of transforming growth factor beta in osteoblasts. Sowa, H., Kaji, H., Iu, M.F., Tsukamoto, T., Sugimoto, T., Chihara, K. J. Biol. Chem. (2003)
- Involvement of Smad signaling in sphingosine 1-phosphate-mediated biological responses of keratinocytes. Sauer, B., Vogler, R., von Wenckstern, H., Fujii, M., Anzano, M.B., Glick, A.B., Schäfer-Korting, M., Roberts, A.B., Kleuser, B. J. Biol. Chem. (2004)
- Smad proteins regulate transcriptional induction of the SM22alpha gene by TGF-beta. Chen, S., Kulik, M., Lechleider, R.J. Nucleic Acids Res. (2003)
- A transforming growth factor beta-induced Smad3/Smad4 complex directly activates protein kinase A. Zhang, L., Duan, C.J., Binkley, C., Li, G., Uhler, M.D., Logsdon, C.D., Simeone, D.M. Mol. Cell. Biol. (2004)
- Essential role of Smad3 in the inhibition of inflammation-induced PPARbeta/delta expression. Tan, N.S., Michalik, L., Di-Poï, N., Ng, C.Y., Mermod, N., Roberts, A.B., Desvergne, B., Wahli, W. EMBO J. (2004)
- Interaction between Smad 3 and Dishevelled in murine embryonic craniofacial mesenchymal cells. Warner, D.R., Greene, R.M., Pisano, M.M. Orthodontics & craniofacial research. (2005)
- Smad3 deficiency ameliorates experimental obliterative bronchiolitis in a heterotopic tracheal transplantation model. Ramirez, A.M., Takagawa, S., Sekosan, M., Jaffe, H.A., Varga, J., Roman, J. Am. J. Pathol. (2004)
- Mechanisms underlying TGF-{beta}1-induced expression of VEGF and Flk-1 in mouse macrophages and their implications for angiogenesis. Jeon, S.H., Chae, B.C., Kim, H.A., Seo, G.Y., Seo, D.W., Chun, G.T., Kim, N.S., Yie, S.W., Byeon, W.H., Eom, S.H., Ha, K.S., Kim, Y.M., Kim, P.H. J. Leukoc. Biol. (2007)
- Myocardin enhances Smad3-mediated transforming growth factor-beta1 signaling in a CArG box-independent manner: Smad-binding element is an important cis element for SM22alpha transcription in vivo. Qiu, P., Ritchie, R.P., Fu, Z., Cao, D., Cumming, J., Miano, J.M., Wang, D.Z., Li, H.J., Li, L. Circ. Res. (2005)
- Both SMAD2 and SMAD3 mediate activin-stimulated expression of the follicle-stimulating hormone beta subunit in mouse gonadotrope cells. Bernard, D.J. Mol. Endocrinol. (2004)
- Analysis of transforming growth factor-beta1-induced Ig germ-line gamma2b transcription and its implication for IgA isotype switching. Park, S.R., Seo, G.Y., Choi, A.J., Stavnezer, J., Kim, P.H. Eur. J. Immunol. (2005)
- Smad-mediated transcription is required for transforming growth factor-beta 1-induced p57(Kip2) proteolysis in osteoblastic cells. Nishimori, S., Tanaka, Y., Chiba, T., Fujii, M., Imamura, T., Miyazono, K., Ogasawara, T., Kawaguchi, H., Igarashi, T., Fujita, T., Tanaka, K., Toyoshima, H. J. Biol. Chem. (2001)
- Unique and redundant roles of Smad3 in TGF-beta-mediated regulation of long bone development in organ culture. Alvarez, J., Serra, R. Dev. Dyn. (2004)
- BMP-7 opposes TGF-beta1-mediated collagen induction in mouse pulmonary myofibroblasts through Id2. Izumi, N., Mizuguchi, S., Inagaki, Y., Saika, S., Kawada, N., Nakajima, Y., Inoue, K., Suehiro, S., Friedman, S.L., Ikeda, K. Am. J. Physiol. Lung Cell Mol. Physiol. (2006)
- p300 cooperates with Smad3/4 and Runx3 in TGFbeta1-induced IgA isotype expression. Park, S.R., Lee, E.K., Kim, B.C., Kim, P.H. Eur. J. Immunol. (2003)
- Smad3 knock-out mice as a useful model to study intestinal fibrogenesis. Zanninelli, G., Vetuschi, A., Sferra, R., D'Angelo, A., Fratticci, A., Continenza, M.A., Chiaramonte, M., Gaudio, E., Caprilli, R., Latella, G. World J. Gastroenterol. (2006)
- Functional analysis of the TGFbeta receptor/Smad pathway through gene ablation in mice. Goumans, M.J., Mummery, C. Int. J. Dev. Biol. (2000)
- Fetal and adult fibroblasts have similar TGF-beta-mediated, Smad-dependent signaling pathways. Colwell, A.S., Krummel, T.M., Longaker, M.T., Lorenz, H.P. Plast. Reconstr. Surg. (2006)