Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

UL12 - deoxyribonuclease

Cercopithecine herpesvirus 2

Zöllner, E.J. et al., Becker, Y. et al., Hoffmann, P.J. et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of UL12

The deoxyribonuclease induced in KB cells by herpes simplex virus (HSV) type 1 and type 2 has been purified [1].
In cells producing defective virus, there was thymidine kinase activity, but the viral deoxyribonuclease activity was considerably reduced [2].

Chemical compound and disease context of UL12

In primary rabbit kidney cells infected with herpes simplex virus four different neutral deoxyribonuclease activities can be detected by means of the deoxyribonuclease assay in DNA-containing polyacrylamide gels following their separation by disc-electrophoresis [3].

References

The deoxyribonuclease induced after infection of KB cells by herpes simplex virus type 1 or type 2. I. Purification and characterization of the enzyme. Hoffmann, P.J., Cheng, Y.C. J. Biol. Chem. (1978) [Pubmed]
Herpes simplex virus DNA polymerase, thymidine kinase and deoxyribonuclease activities in cells infected with wild type, ultraviolet-irradiated and defective virus. Becker, Y., Gutter, B., Cohen, Y., Chejanovsky, N., Rabkin, S., Fridlender, B. Arch. Virol. (1979) [Pubmed]
Deoxyribonucleases in herpes simplex virus type 1 and 2 infected primary rabbit kidney cells. Zöllner, E.J., Zahn, R.K., Falke, D. Z. Naturforsch., C, Biosci. (1980) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.