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MeSH Review

Defective Viruses

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Disease relevance of Defective Viruses


High impact information on Defective Viruses

  • The selection of recombinant viruses containing the S4 gene derived from the defective virus was specific for persistent infection, since it was not selected in lytic infections [6].
  • The SVX HPRT B defective virus partially corrected the HPRT deficiency (4 to 56% of normal) of cultured rodent and human Lesch-Nyhan cells [7].
  • The gp55 was purified from this defective virus by concanavalin A and heparin affinity chromatography, as well as by preparative sodium dodecyl sulfate-gel electrophoresis [8].
  • We have used this pro-apoptotic property of the p35 null virus to screen for genes encoding inhibitors of apoptosis that rescue cells infected with the p35 defective virus [9].
  • These abnormalities were associated with presence of the MAIDS-inducing defective virus genome, but were not induced by infection of mice genetically resistant to development of MAIDS or with nonpathogenic helper murine leukemia virus, a virus component that induces high spontaneous proliferation of T cells, even in MAIDS-resistant mice [10].

Chemical compound and disease context of Defective Viruses


Biological context of Defective Viruses


Anatomical context of Defective Viruses


Gene context of Defective Viruses

  • This truncated NP protein was identified in cells naturally infected with the defective virus preparation [23].
  • Enzymatic deglycosylation confirmed that erythropoietin was cross-linked with the envelope protein of the defective virus and bidimensional diagonal gel electrophoresis analyses showed that some of the erythropoietin cross-linked envelope proteins were dimerized by disulfide bonds [21].
  • To overcome these difficulties we developed a TMV helper virus-defective RNA (dRNA) system to study the role of replicase protein sequences in dRNA cell-to-cell movement [24].
  • Whereas Akv-3 is known to encode a defective virus, Akv-4 has been shown to code for an infectious virus thought to be very similar or identical to that of Akv-1 [25].
  • The defective interfering particles of Wa-182 were devoid of the PA gene (RNA segment 3) but possessed several species of subgenomic RNAs of the PA gene origin [1].

Analytical, diagnostic and therapeutic context of Defective Viruses


  1. Mutation in NS2, a nonstructural protein of influenza A virus, extragenically causes aberrant replication and expression of the PA gene and leads to generation of defective interfering particles. Odagiri, T., Tobita, K. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  2. Two types of defective human T-lymphotropic virus type I provirus in adult T-cell leukemia. Tamiya, S., Matsuoka, M., Etoh, K., Watanabe, T., Kamihira, S., Yamaguchi, K., Takatsuki, K. Blood (1996) [Pubmed]
  3. Retroviral-mediated gene transfer in human bone marrow cells growth in continuous perfusion culture vessels. Eipers, P.G., Krauss, J.C., Palsson, B.O., Emerson, S.G., Todd, R.F., Clarke, M.F. Blood (1995) [Pubmed]
  4. Encapsidation of Sendai virus genome RNAs by purified NP protein during in vitro replication. Baker, S.C., Moyer, S.A. J. Virol. (1988) [Pubmed]
  5. Role of glycoprotein gIII of pseudorabies virus in virulence. Mettenleiter, T.C., Schreurs, C., Zuckermann, F., Ben-Porat, T., Kaplan, A.S. J. Virol. (1988) [Pubmed]
  6. Role of the S4 gene in the establishment of persistent reovirus infection in L cells. Ahmed, R., Fields, B.N. Cell (1982) [Pubmed]
  7. Construction of a defective retrovirus containing the human hypoxanthine phosphoribosyltransferase cDNA and its expression in cultured cells and mouse bone marrow. Chang, S.M., Wager-Smith, K., Tsao, T.Y., Henkel-Tigges, J., Vaishnav, S., Caskey, C.T. Mol. Cell. Biol. (1987) [Pubmed]
  8. 55,000-dalton, retrovirus-associated, cell membrane glycoprotein: purification and quantitative measurements of expression in viruses, cells, and tissues. Scheinberg, D.A., Strand, M. Mol. Cell. Biol. (1981) [Pubmed]
  9. Baculovirus-based genetic screen for antiapoptotic genes identifies a novel IAP. Seshagiri, S., Vucic, D., Lee, J., Dixit, V.M. J. Biol. Chem. (1999) [Pubmed]
  10. Impaired calcium mobilization in CD4+ and CD8+ T cells in a retrovirus-induced immunodeficiency syndrome, murine AIDS. Makino, M., Sei, Y., Arora, P.K., Morse, H.C., Hartley, J.W. J. Immunol. (1992) [Pubmed]
  11. Chemotherapy of herpetic keratitis induced by acyclovir-resistant strains of herpes simplex virus type 1. O'Brien, W.J., Taylor, J.L. Am. J. Med. (1982) [Pubmed]
  12. Ascorbate stabilizes the differentiated state and reduces the ability of Rous sarcoma virus to replicate and to uniformly transform cell cultures. Schwarz, R.I. Am. J. Clin. Nutr. (1991) [Pubmed]
  13. Host function-dependent induction of defective interfering particles of vesicular stomatitis virus. Kang, C.Y., Allen, R. J. Virol. (1978) [Pubmed]
  14. Biochemical studies on bovine adenovirus type 3. II. Incomplete virus. Igarashi, K., Niiyama, Y., Tsukamoto, K., Kurokawa, T., Sugino, Y. J. Virol. (1975) [Pubmed]
  15. Characterization of virulent and avirulent A/chicken/Pennsylvania/83 influenza A viruses: potential role of defective interfering RNAs in nature. Bean, W.J., Kawaoka, Y., Wood, J.M., Pearson, J.E., Webster, R.G. J. Virol. (1985) [Pubmed]
  16. Identification of the threonine phosphorylation sites on the polyomavirus major capsid protein VP1: relationship to the activity of middle T antigen. Li, M., Garcea, R.L. J. Virol. (1994) [Pubmed]
  17. Herpes simplex virus type 1 evades the effects of antibody and complement in vivo. Lubinski, J.M., Jiang, M., Hook, L., Chang, Y., Sarver, C., Mastellos, D., Lambris, J.D., Cohen, G.H., Eisenberg, R.J., Friedman, H.M. J. Virol. (2002) [Pubmed]
  18. trans-Complementation of flavivirus RNA polymerase gene NS5 by using Kunjin virus replicon-expressing BHK cells. Khromykh, A.A., Kenney, M.T., Westaway, E.G. J. Virol. (1998) [Pubmed]
  19. Epstein-Barr virus gene expression in P3HR1-superinfected Raji cells. Biggin, M., Bodescot, M., Perricaudet, M., Farrell, P. J. Virol. (1987) [Pubmed]
  20. Vaccinia virus envelope H3L protein binds to cell surface heparan sulfate and is important for intracellular mature virion morphogenesis and virus infection in vitro and in vivo. Lin, C.L., Chung, C.S., Heine, H.G., Chang, W. J. Virol. (2000) [Pubmed]
  21. Multimeric structure of the membrane erythropoietin receptor of murine erythroleukemia cells (Friend cells). Cross-linking of erythropoietin with the spleen focus-forming virus envelope protein. Casadevall, N., Lacombe, C., Muller, O., Gisselbrecht, S., Mayeux, P. J. Biol. Chem. (1991) [Pubmed]
  22. Modulation of mucosal and systemic immunity by enteric administration of nonreplicating herpes simplex virus expressing cytokines. Kuklin, N.A., Daheshia, M., Marconi, P.C., Krisky, D.M., Rouse, R.J., Glorioso, J.C., Manican, E., Rouse, B.T. Virology (1998) [Pubmed]
  23. Molecular cloning and characterization of a Sendai virus internal deletion defective RNA. Engelhorn, M., Stricker, R., Roux, L. J. Gen. Virol. (1993) [Pubmed]
  24. A bipartite Tobacco mosaic virus-defective RNA (dRNA) system to study the role of the N-terminal methyl transferase domain in cell-to-cell movement of dRNAs. Knapp, E., Danyluk, G.M., Achor, D., Lewandowski, D.J. Virology (2005) [Pubmed]
  25. Cytolytic T lymphocyte-defined retroviral antigens on normal cells: encoding by the Akv-1 proviral locus. Green, W.R., Graziano, R.F. Immunogenetics (1986) [Pubmed]
  26. Defective herpes simplex virus DNA: circular and circular-linear molecules resembling rolling circles. Becker, Y., Asher, Y., Weinberg-Zahlering, E., Rabkin, S., Friedmann, A., Kessler, E. J. Gen. Virol. (1978) [Pubmed]
  27. Chronic non-cytopathic infection of human continuous cell lines with mumps virus. Andzhaparidze, O.G., Bogomolova, N.N., Boriskin YuS, n.u.l.l., Drynov, I.D. Acta Virol. (1983) [Pubmed]
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