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Gene Review

rpoD1  -  RNA polymerase sigma factor RpoD

Synechococcus elongatus PCC 6301

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Disease relevance of rpoD1

  • All of the holoenzymes recognized canonical promoters of Escherichia coli as well as cyanobacterial rrnA, cpcB1A1 P1a and rpoD1 promoters, although the three holoenzymes had some preference for specific promoters [1].
  • We performed molecular characterization of the RpoD1 protein encoded by the rpoD1 gene isolated from a cyanobacterium, Microcystis aeruginosa K-81 [2].
  • The complete nucleotide sequence of rpoD1 gene from Synechococcus PCC7942 has been determined [3].
  • The rpoD1 gene showed the greatest similarity to the sigA gene of Anabaena sp. PCC7120 [4].

High impact information on rpoD1

  • An RNA polymerase core enzyme of the cyanobacterial strain was purified, reconstituted with the recombinant sigma factors (the rpoD1, rpoD3 and rpoD4 gene products), and the resultant holoenzymes were examined in vitro for transcription specificity [1].


  1. Specificity crosstalk among group 1 and group 2 sigma factors in the cyanobacterium Synechococcus sp. PCC7942: In vitro specificity and a phylogenetic analysis. Goto-Seki, A., Shirokane, M., Masuda, S., Tanaka, K., Takahashi, H. Mol. Microbiol. (1999) [Pubmed]
  2. The rpoD1 gene product is a principal sigma factor of RNA polymerase in Microcystis aeruginosa K-81. Asayama, M., Suzuki, H., Sato, A., Aida, T., Tanaka, K., Takahashi, H., Shirai, M. J. Biochem. (1996) [Pubmed]
  3. The complete nucleotide sequence of the gene (rpoD1) encoding the principal sigma factor of the RNA polymerase from the cyanobacterium Synechococcus sp. strain PCC7942. Tanaka, K., Masuda, S., Takahashi, H. Biochim. Biophys. Acta (1992) [Pubmed]
  4. Multiple rpoD-related genes of cyanobacteria. Tanaka, K., Masuda, S., Takahashi, H. Biosci. Biotechnol. Biochem. (1992) [Pubmed]
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