Gene Review:
agt - angiotensinogen
Danio rerio
Synonyms:
SO:0000704, wu:fb62f06, wu:fj87b02, zgc:111892
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High impact information on agt
- The effect of Ang II stimulation on angiotensinogen expression is more potent in fish than that in mammals [1].
- Angiotensin II (Ang II) stimulates the production and secretion of angiotensinogen in many mammalian models [1].
- The nucleotide sequence of angiotensinogen for S. sarba only exhibits a fair resemblance to other fish angiotensinogens and shows 76.6% similarity to that of Takifugu rubripes and 57.2% similarity to that of Danio rerio [1].
- Blockade of endogenous RAS by the angiotensin converting enzyme (ACE) inhibitor, captopril, significantly lowered the hepatic expression of angiotensinogen in vivo [1].
- A positive feedback mechanism of angiotensinogen by Ang II has been demonstrated as exogenous Ang II increased the amount of angiotensinogen transcript in isolated hepatocytes in vitro [1].
References
- Positive feedback of hepatic angiotensinogen expression in silver sea bream (Sparus sarba). Wong, M.K., Ge, W., Woo, N.Y. Mol. Cell. Endocrinol. (2007) [Pubmed]
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