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Gene Review

aldh1a2  -  aldehyde dehydrogenase 1 family, member A2

Danio rerio

Synonyms: SO:0000704, fb50h01, raldh2
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High impact information on aldh1a2

  • Mutants in aldh1a2 (raldh2), an embryonically expressed gene encoding a retinoic acid (RA)-synthesizing enzyme, have been used to show that limb development and patterning of the limb bud are crucially dependent on RA signaling [1].
  • The zebrafish neckless mutation reveals a requirement for raldh2 in mesodermal signals that pattern the hindbrain [2].
  • During embryogenesis, lratb is expressed in mostly non-overlapping domains opposite to retinal dehydrogenase 2 (raldh2), the key enzyme for retinoic acid synthesis [3].
  • Further, we have found that although APC mutants are deficient in rdh1l expression, they harbor increased expression of raldh2 suggesting the control of RA production by APC is via retinol dehydrogenase activity [4].
  • Tests of the raldh2 promoter in cell transfections proved that RA directly represses its activity [5].

Associations of aldh1a2 with chemical compounds

  • Here we have analyzed the formation of primary and secondary hindbrain neurons in the zebrafish mutant neckless (nls), which disrupts retinaldehyde dehydrogenase 2 (raldh2), and in embryos treated with retinoid receptor (RAR) antagonists [6].


  1. Induction and prepatterning of the zebrafish pectoral fin bud requires axial retinoic acid signaling. Gibert, Y., Gajewski, A., Meyer, A., Begemann, G. Development (2006) [Pubmed]
  2. The zebrafish neckless mutation reveals a requirement for raldh2 in mesodermal signals that pattern the hindbrain. Begemann, G., Schilling, T.F., Rauch, G.J., Geisler, R., Ingham, P.W. Development (2001) [Pubmed]
  3. Sequestration of retinyl esters is essential for retinoid signaling in the zebrafish embryo. Isken, A., Holzschuh, J., Lampert, J.M., Fischer, L., Oberhauser, V., Palczewski, K., von Lintig, J. J. Biol. Chem. (2007) [Pubmed]
  4. The zebrafish retinol dehydrogenase, rdh1l, is essential for intestinal development and is regulated by the tumor suppressor adenomatous polyposis coli. Nadauld, L.D., Shelton, D.N., Chidester, S., Yost, H.J., Jones, D.A. J. Biol. Chem. (2005) [Pubmed]
  5. Feedback mechanisms regulate retinoic acid production and degradation in the zebrafish embryo. Dobbs-McAuliffe, B., Zhao, Q., Linney, E. Mech. Dev. (2004) [Pubmed]
  6. Independent roles for retinoic acid in segmentation and neuronal differentiation in the zebrafish hindbrain. Linville, A., Gumusaneli, E., Chandraratna, R.A., Schilling, T.F. Dev. Biol. (2004) [Pubmed]
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