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Gene Review:

NFAT - NFAT homolog

Drosophila melanogaster

Synonyms: CG11172, Dmel\CG11172, EP1335, MESR1, NF-AT5, ...

Corbo, J.C. et al., Feske, S. et al., Gwack, Y. et al., Ip, Y.T. et al., Rushlow, C. et al., et al.

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High impact information on NFAT

We present evidence that the DNA-binding activity of the dl protein is mediated by the region of homology (the rel domain) conserved in the rel and NF-kappa B proteins [1].
The rel family of proteins can be defined as a group of proteins that share sequence homology over a 300 amino acid region termed the rel domain [2].
In an effort to identify additional components that influence Rel-domain gene function we have conducted a search for immunodeficiency mutants in Drosophila [3].
Drosophila immunity and embryogenesis appear to be linked by an evolutionarily ancient signalling pathway, which includes the Rel-domain transcription factors Dif and dorsal, respectively, as well as a common inhibitor, cactus [3].
The NFAT gene encodes the only homolog in Drosophila of the five human Nuclear Factors of Activated T-cells, NFAT1-5 [4].

Biological context of NFAT

Here we have used a genome-wide RNA interference (RNAi) screen in Drosophila to identify additional regulators of the signalling pathway leading from Ca2+-calcineurin to NFAT [5].
Here we identify the genetic defect in these patients, using a combination of two unbiased genome-wide approaches: a modified linkage analysis with single-nucleotide polymorphism arrays, and a Drosophila RNA interference screen designed to identify regulators of store-operated Ca2+ entry and NFAT nuclear import [6].

References

The dorsal morphogen is a sequence-specific DNA-binding protein that interacts with a long-range repression element in Drosophila. Ip, Y.T., Kraut, R., Levine, M., Rushlow, C.A. Cell (1991) [Pubmed]
The rel family of proteins. Rushlow, C., Warrior, R. Bioessays (1992) [Pubmed]
Characterization of an immunodeficiency mutant in Drosophila. Corbo, J.C., Levine, M. Mech. Dev. (1996) [Pubmed]
The Drosophila NFAT homolog is involved in salt stress tolerance. Keyser, P., Borge-Renberg, K., Hultmark, D. Insect Biochem. Mol. Biol. (2007) [Pubmed]
A genome-wide Drosophila RNAi screen identifies DYRK-family kinases as regulators of NFAT. Gwack, Y., Sharma, S., Nardone, J., Tanasa, B., Iuga, A., Srikanth, S., Okamura, H., Bolton, D., Feske, S., Hogan, P.G., Rao, A. Nature (2006) [Pubmed]
A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function. Feske, S., Gwack, Y., Prakriya, M., Srikanth, S., Puppel, S.H., Tanasa, B., Hogan, P.G., Lewis, R.S., Daly, M., Rao, A. Nature (2006) [Pubmed]

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