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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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fbe  -  fibronectin/fibrinogen binding protein

Staphylococcus epidermidis RP62A

 
 
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Disease relevance of fbe

  • We explored three genes of attachment (fbe and atlE) and adhesion (ica) in 27 and 10 Staphylococcus epidermidis strains involved in pacemaker-related infections (PMI) and intravascular-catheter-related infections (IVCI), respectively, and in 25 saprophytic strains [1].
 

High impact information on fbe

  • By additional cloning and DNA sequence analyses, the complete gene, termed fbe, was found to consist of an open reading frame of 3,276 nucleotides encoding a protein, called Fbe, with a deduced molecular mass of approximately 119 kDa [2].
  • The detection rates of fbe and atlE were identical in PMI and IVCI strains, but ica detection rates were identical in PMI and saprophytic strains [1].
  • The plasmid integrated into the chromosomal fbe gene at a frequency of 2.8 x 10(-4) [3].
  • A fbe mutant was constructed by allelic replacement, where a Gentamicin resistance gene replaced a portion of the A region of fbe [4].
 

Analytical, diagnostic and therapeutic context of fbe

  • PCR analysis showed that the fbe gene was found in 40 of 43 clinical isolates of S. epidermidis [2].

References

  1. Involvement of adherence and adhesion Staphylococcus epidermidis genes in pacemaker lead-associated infections. Klug, D., Wallet, F., Kacet, S., Courcol, R.J. J. Clin. Microbiol. (2003) [Pubmed]
  2. A fibrinogen-binding protein of Staphylococcus epidermidis. Nilsson, M., Frykberg, L., Flock, J.I., Pei, L., Lindberg, M., Guss, B. Infect. Immun. (1998) [Pubmed]
  3. The Fbe (SdrG) protein of Staphylococcus epidermidis HB promotes bacterial adherence to fibrinogen. Hartford, O., O'Brien, L., Schofield, K., Wells, J., Foster, T.J. Microbiology (Reading, Engl.) (2001) [Pubmed]
  4. Lack of fbe, the gene for a fibrinogen-binding protein from Staphylococcus epidermidis, reduces its adherence to fibrinogen coated surfaces. Pei, L., Flock, J.I. Microb. Pathog. (2001) [Pubmed]
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