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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Ac13E  -  Adenylyl cyclase 35C

Drosophila melanogaster

Synonyms: AC 13E, AC13E, Ac35C, CG9210, DAC9, ...
 
 
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Disease relevance of Ac13E

 

High impact information on Ac13E

  • We have generated transgenic mice in which the expression of a constitutively active form of G(s)alpha (G(s)alpha* Q227L), the G protein that stimulates adenylyl cyclase activity, is driven in neurons within the forebrain by the promoter from the CaMKIIalpha gene [2].
  • Despite significantly increased adenylyl cyclase activity, G(s)alpha* transgenic mice exhibit PKA-dependent decreases in levels of cAMP due to a compensatory up-regulation in phosphodiesterase activity [2].

References

  1. The human synaptotagmin IV gene defines an evolutionary break point between syntenic mouse and human chromosome regions but retains ligand inducibility and tissue specificity. Ferguson, G.D., Chen, X.N., Korenberg, J.R., Herschman, H.R. J. Biol. Chem. (2000) [Pubmed]
  2. Chronically increased Gs{alpha} signaling disrupts associative and spatial learning. Bourtchouladze, R., Patterson, S.L., Kelly, M.P., Kreibich, A., Kandel, E.R., Abel, T. Learn. Mem. (2006) [Pubmed]
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