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Gene Review

sp8b  -  sp8 transcription factor b

Danio rerio

Synonyms: SO:0000704, Sp8, Sp8a, Transcription factor Sp8, fc48e06, ...
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High impact information on sp8l

  • In this report, we describe the identification of zebrafish Pur alpha and Sp8 orthologs as two factors that function to regulate neuronal expression of gata2 [1].
  • Recently, the phenotype of Sp8 null mice has been described, being tailless and having severe truncation of both fore and hind limbs [2].

Biological context of sp8l


  1. Pur alpha and Sp8 as opposing regulators of neural gata2 expression. Penberthy, W.T., Zhao, C., Zhang, Y., Jessen, J.R., Yang, Z., Bricaud, O., Collazo, A., Meng, A., Lin, S. Dev. Biol. (2004) [Pubmed]
  2. Genomic structure and cloning of two transcript isoforms of human Sp8. Milona, M.A., Gough, J.E., Edgar, A.J. BMC Genomics (2004) [Pubmed]
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