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Gene Review

Sp8  -  trans-acting transcription factor 8

Mus musculus

Synonyms: D930049B17Rik, Transcription factor Sp8, mBtd
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Disease relevance of Sp8

  • Targeted deletion of the Sp8 gene gives a striking phenotype, with severe truncation of both forelimbs and hindlimbs, absent tail, as well as defects in anterior and posterior neuropore closure leading to exencephaly and spina bifida [1].

High impact information on Sp8

  • Moreover, mutant neuroblasts/interneurons are misspecified and display abnormal migration patterns in the olfactory bulb, indicating that Sp8 contributes to olfactory bulb interneuron diversity by regulating the survival, migration, and molecular specification of neuroblasts/interneurons [2].
  • Sp8 conditional mutants exhibit an increase in cell death within the lateral ganglionic eminence and rostral migratory stream [2].
  • In this report we describe the developmental expression and function of Sp8, a member of the Sp family of zinc finger transcription factors, and provide evidence that the legless transgene insertional mutant is a hypomorphic allele of the Sp8 gene [1].
  • Sp8 is expressed during embryogenesis in the forming apical ectodermal ridge (AER), restricted regions of the central nervous system, and tail bud [1].
  • Furthermore, we provide evidence that cell proliferation in the mid- and hindbrain is tightly controlled by Sp8 activity [3].

Anatomical context of Sp8

  • Conditional inactivation of Sp8 in the embryonic ventral telencephalon reveals a requirement for the normal generation of these interneuron subtypes [2].

Regulatory relationships of Sp8


  1. Sp8 is crucial for limb outgrowth and neuropore closure. Bell, S.M., Schreiner, C.M., Waclaw, R.R., Campbell, K., Potter, S.S., Scott, W.J. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  2. The zinc finger transcription factor Sp8 regulates the generation and diversity of olfactory bulb interneurons. Waclaw, R.R., Allen, Z.J., Bell, S.M., Erdélyi, F., Szabó, G., Potter, S.S., Campbell, K. Neuron (2006) [Pubmed]
  3. Sp8 controls the anteroposterior patterning at the midbrain-hindbrain border. Griesel, G., Treichel, D., Collombat, P., Krull, J., Zembrzycki, A., van den Akker, W.M., Gruss, P., Simeone, A., Mansouri, A. Development (2006) [Pubmed]
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