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Gene Review:

Aia3 - Adjuvant induced arthritis QTL 3

Rattus norvegicus

Kawahito, Y. et al., Joe, B. et al.

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Disease relevance of Aia3

Interestingly, the QTL region on chromosome 4 (Aia3/Cia3), like the MHC, appears to be involved in several other autoimmune diseases in rats, including insulin-dependent diabetes, thyroiditis, and experimental autoimmune uveitis [1].

High impact information on Aia3

The arthritis-lowering effects of Aia2 and Aia3 were sex-influenced and were therefore observed in only males and only females, respectively [2].

References

Localization of quantitative trait loci regulating adjuvant-induced arthritis in rats: evidence for genetic factors common to multiple autoimmune diseases. Kawahito, Y., Cannon, G.W., Gulko, P.S., Remmers, E.F., Longman, R.E., Reese, V.R., Wang, J., Griffiths, M.M., Wilder, R.L. J. Immunol. (1998) [Pubmed]
Evaluation of quantitative trait loci regulating severity of mycobacterial adjuvant-induced arthritis in monocongenic and polycongenic rats: identification of a new regulatory locus on rat chromosome 10 and evidence of overlap with rheumatoid arthritis susceptibility loci. Joe, B., Cannon, G.W., Griffiths, M.M., Dobbins, D.E., Gulko, P.S., Wilder, R.L., Remmers, E.F. Arthritis Rheum. (2002) [Pubmed]

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