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Disease relevance of Uveitis


Psychiatry related information on Uveitis

  • We have studied 44 sera of patients with uveitis, and controls for the presence of ANF and other antinuclear antibodies (ss-DNA, ds-DNA, Poly (I), Poly (G), RNP, Sm, histones) and for the presence of a common anti-DNA idiotype (16/6 Id) employing the ELISA method [6].

High impact information on Uveitis

  • There were fewer episodes of hypopyon uveitis (1 vs. 15; P less than 0.001) among the group 2 patients who took azathioprine [7].
  • Saving the vision of children with juvenile rheumatoid arthritis-associated uveitis [8].
  • Bilateral uveitis was the initial manifestation of a limited form of Wegener granulomatosis in a 47-year-old man [9].
  • Susceptibility to experimental autoimmune uveitis (EAU), a model for human uveitis induced in mice with the retinal antigen interphotoreceptor retinoid-binding protein (IRBP), is controlled by "natural" CD4(+)CD25(+) regulatory T (T reg) cells [10].
  • Experimental autoimmune uveitis (EAU) is a disease of the neural retina induced by immunization with retinal antigens, such as interphotoreceptor retinoid-binding protein (IRBP) and arrestin (retinal soluble antigen, S-Ag) [11].

Chemical compound and disease context of Uveitis


Biological context of Uveitis


Anatomical context of Uveitis

  • In a model of low-dose endotoxin-induced uveitis, anti-LOX-1 antibody efficiently suppressed leukocyte infiltration and protein exudation [22].
  • Autoimmune encephalomyelitis and uveitis induced by T cell immunity to self beta-synuclein [23].
  • We show here that ocular lymphocytes isolated from patients with uveitis who had been treated with topical glucocorticoids expressed highly elevated levels of CXCR4 [24].
  • In addition, the induced CD56(bright) cells could secrete large amounts of IL-10 whereas CD56(dim) NK cells could not, suggesting that the induction of the CD56(bright) cells may have a beneficial effect on the remission of active uveitis [25].
  • The severity of uveitis was evaluated clinically at 16 hours, and nitrite levels were evaluated in the aqueous humor at 8 hours [26].

Gene context of Uveitis


Analytical, diagnostic and therapeutic context of Uveitis


  1. Risk factors for cyclosporine-induced nephropathy in patients with autoimmune diseases. International Kidney Biopsy Registry of Cyclosporine in Autoimmune Diseases. Feutren, G., Mihatsch, M.J. N. Engl. J. Med. (1992) [Pubmed]
  2. Interleukin 12 protects from a T helper type 1-mediated autoimmune disease, experimental autoimmune uveitis, through a mechanism involving interferon gamma, nitric oxide, and apoptosis. Tarrant, T.K., Silver, P.B., Wahlsten, J.L., Rizzo, L.V., Chan, C.C., Wiggert, B., Caspi, R.R. J. Exp. Med. (1999) [Pubmed]
  3. Arthritis, uveitis, and Stevens-Johnson syndrome induced by trimethoprim. Arola, O., Peltonen, R., Rossi, T. Lancet (1998) [Pubmed]
  4. Genetic linkage of autosomal dominant neovascular inflammatory vitreoretinopathy to chromosome 11q13. Stone, E.M., Kimura, A.E., Folk, J.C., Bennett, S.R., Nichols, B.E., Streb, L.M., Sheffield, V.C. Hum. Mol. Genet. (1992) [Pubmed]
  5. Oral tolerance for the treatment of autoimmune diseases. Weiner, H.L. Annu. Rev. Med. (1997) [Pubmed]
  6. Antinuclear autoantibodies in uveitis. Hundert, I., Bakimer, R., Amital-Teplizki, H., Slor, H., Yassur, Y., Palestine, A., Nussenblatt, R.B., Shoenfeld, Y. Clinical and experimental rheumatology. (1989) [Pubmed]
  7. A controlled trial of azathioprine in Behçet's syndrome. Yazici, H., Pazarli, H., Barnes, C.G., Tüzün, Y., Ozyazgan, Y., Silman, A., Serdaroğlu, S., Oğuz, V., Yurdakul, S., Lovatt, G.E. N. Engl. J. Med. (1990) [Pubmed]
  8. Saving the vision of children with juvenile rheumatoid arthritis-associated uveitis. Nguyen, Q.D., Foster, C.S. JAMA (1998) [Pubmed]
  9. Limited form of Wegener granulomatosis. Eye involvement as a major sign. Coutu, R.E., Klein, M., Lessell, S., Friedman, E., Snider, G.L. JAMA (1975) [Pubmed]
  10. Endogenous IRBP can be dispensable for generation of natural CD4+CD25+ regulatory T cells that protect from IRBP-induced retinal autoimmunity. Grajewski, R.S., Silver, P.B., Agarwal, R.K., Su, S.B., Chan, C.C., Liou, G.I., Caspi, R.R. J. Exp. Med. (2006) [Pubmed]
  11. A humanized model of experimental autoimmune uveitis in HLA class II transgenic mice. Pennesi, G., Mattapallil, M.J., Sun, S.H., Avichezer, D., Silver, P.B., Karabekian, Z., David, C.S., Hargrave, P.A., McDowell, J.H., Smith, W.C., Wiggert, B., Donoso, L.A., Chan, C.C., Caspi, R.R. J. Clin. Invest. (2003) [Pubmed]
  12. Renal histopathologic alterations in patients treated with cyclosporine for uveitis. Palestine, A.G., Austin, H.A., Balow, J.E., Antonovych, T.T., Sabnis, S.G., Preuss, H.G., Nussenblatt, R.B. N. Engl. J. Med. (1986) [Pubmed]
  13. Cyclosporin a. Inhibition of experimental autoimmune uveitis in Lewis rats. Nussenblatt, R.B., Rodrigues, M.M., Wacker, W.B., Cevario, S.J., Salinas-Carmona, M.C., Gery, I. J. Clin. Invest. (1981) [Pubmed]
  14. Rescue therapy with mycophenolate mofetil in refractory uveitis. Kilmartin, D.J., Forrester, J.V., Dick, A.D. Lancet (1998) [Pubmed]
  15. Hypotensive effect of timolol on secondary glaucoma in chronic uveitis. Saari, K.M., Airaksinen, P.J., Jaanio, E.A. Lancet (1978) [Pubmed]
  16. Treatment of chronic endogenous uveitis with fusidic acid. Bendtzen, K., Vesti-Nielsen, N., Petersen, J., Andersen, V., Bendixen, G. Lancet (1991) [Pubmed]
  17. Do tumor necrosis factor inhibitors cause uveitis? A registry-based study. Lim, L.L., Fraunfelder, F.W., Rosenbaum, J.T. Arthritis Rheum. (2007) [Pubmed]
  18. Autoantigens signal through chemokine receptors: uveitis antigens induce CXCR3- and CXCR5-expressing lymphocytes and immature dendritic cells to migrate. Howard, O.M., Dong, H.F., Su, S.B., Caspi, R.R., Chen, X., Plotz, P., Oppenheim, J.J. Blood (2005) [Pubmed]
  19. Evidence for selective accumulation of V beta 8+ T lymphocytes in experimental autoimmune uveoretinitis induced with two different retinal antigens. Egwuagu, C.E., Mahdi, R.M., Nussenblatt, R.B., Gery, I., Caspi, R.R. J. Immunol. (1993) [Pubmed]
  20. Kinetics of intraocular tumor necrosis factor and interleukin-6 in endotoxin-induced uveitis in the rat. de Vos, A.F., van Haren, M.A., Verhagen, C., Hoekzema, R., Kijlstra, A. Invest. Ophthalmol. Vis. Sci. (1994) [Pubmed]
  21. Long-term cytogenetic follow-up study of patients with uveitis treated with chlorambucil. Reeves, B.R., Casey, G., Harris, H., Dinning, W.J. Carcinogenesis (1985) [Pubmed]
  22. Lectin-like oxidized LDL receptor-1 is a cell-adhesion molecule involved in endotoxin-induced inflammation. Honjo, M., Nakamura, K., Yamashiro, K., Kiryu, J., Tanihara, H., McEvoy, L.M., Honda, Y., Butcher, E.C., Masaki, T., Sawamura, T. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  23. Autoimmune encephalomyelitis and uveitis induced by T cell immunity to self beta-synuclein. Mor, F., Quintana, F., Mimran, A., Cohen, I.R. J. Immunol. (2003) [Pubmed]
  24. Topical glucocorticoid therapy directly induces up-regulation of functional CXCR4 on primed T lymphocytes in the aqueous humor of patients with uveitis. Curnow, S.J., Wloka, K., Faint, J.M., Amft, N., Cheung, C.M., Savant, V., Lord, J., Akbar, A.N., Buckley, C.D., Murray, P.I., Salmon, M. J. Immunol. (2004) [Pubmed]
  25. Cutting edge: in vivo blockade of human IL-2 receptor induces expansion of CD56(bright) regulatory NK cells in patients with active uveitis. Li, Z., Lim, W.K., Mahesh, S.P., Liu, B., Nussenblatt, R.B. J. Immunol. (2005) [Pubmed]
  26. Reduction of corneal edema in endotoxin-induced uveitis after application of L-NAME as nitric oxide synthase inhibitor in rats by iontophoresis. Behar-Cohen, F.F., Savoldelli, M., Parel, J.M., Goureau, O., Thillaye-Goldenberg, B., Courtois, Y., Pouliquen, Y., de Kozak, Y. Invest. Ophthalmol. Vis. Sci. (1998) [Pubmed]
  27. Disruption of CD40/CD40-ligand interactions in a retinal autoimmunity model results in protection without tolerance. Bagenstose, L.M., Agarwal, R.K., Silver, P.B., Harlan, D.M., Hoffmann, S.C., Kampen, R.L., Chan, C.C., Caspi, R.R. J. Immunol. (2005) [Pubmed]
  28. Inhibition of endotoxin-induced uveitis and potentiation of local TNF-alpha and interleukin-6 mRNA expression by interleukin-13. Marie, O., Thillaye-Goldenberg, B., Naud, M.C., de Kozak, Y. Invest. Ophthalmol. Vis. Sci. (1999) [Pubmed]
  29. Analysis of immunoregulatory cytokines in ocular fluid samples from patients with uveitis. Ongkosuwito, J.V., Feron, E.J., van Doornik, C.E., Van der Lelij, A., Hoyng, C.B., La Heij, E.C., Kijlstra, A. Invest. Ophthalmol. Vis. Sci. (1998) [Pubmed]
  30. Increased CD4+ expression and decreased IL-10 in the anterior chamber in idiopathic uveitis. Calder, V.L., Shaer, B., Muhaya, M., Mclauchlan, M., Pearson, R.V., Jolly, G., Towler, H.M., Lightman, S. Invest. Ophthalmol. Vis. Sci. (1999) [Pubmed]
  31. Retroviral gene therapy with an immunoglobulin-antigen fusion construct protects from experimental autoimmune uveitis. Agarwal, R.K., Kang, Y., Zambidis, E., Scott, D.W., Chan, C.C., Caspi, R.R. J. Clin. Invest. (2000) [Pubmed]
  32. Immunomodulation of experimental autoimmune diseases via oral tolerance. Krause, I., Blank, M., Shoenfeld, Y. Crit. Rev. Immunol. (2000) [Pubmed]
  33. The role of tumour necrosis factor (TNF-alpha) in experimental autoimmune uveoretinitis (EAU). Dick, A.D., Forrester, J.V., Liversidge, J., Cope, A.P. Progress in retinal and eye research. (2004) [Pubmed]
  34. Cross-reactivity between an HLA-B27-derived peptide and a retinal autoantigen peptide: a clue to major histocompatibility complex association with autoimmune disease. Wildner, G., Thurau, S.R. Eur. J. Immunol. (1994) [Pubmed]
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