The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Thyroiditis


Psychiatry related information on Thyroiditis


High impact information on Thyroiditis

  • Thyroiditis and hepatitis: Fas on the road to disease [7].
  • AIT is primarily related to excess iodine-induced thyroid hormone synthesis in an abnormal thyroid gland (type I AIT) or to amiodarone-related destructive thyroiditis (type II AIT), but mixed forms frequently exist [8].
  • The mechanisms responsible for thyrocyte destruction in Hashimoto's thyroiditis (HT) are poorly understood [9].
  • After autoimmune inflammation, interactions between CD95 and its ligand (CD95L) mediate thyrocyte destruction in Hashimoto's thyroiditis (HT) [10].
  • Total body and regional bone mineral density (BMD) levels were determined in 26 premenopausal women with Hashimoto's thyroiditis receiving long-term physiological doses of levothyroxine sodium replacement therapy [11].

Chemical compound and disease context of Thyroiditis

  • Histological examination revealed a marked thyroiditis in hTg-only animals and a significantly reduced degree of mononuclear cell infiltration and follicular destruction in the M plus T4-treated groups (graded 1.9 compared with 3.6 in hTg-only P = less than 0.01) [12].
  • B cells infiltrating inflamed tissues like in Hashimoto's thyroiditis, also expressed these selectin-binding carbohydrates in parallel with the expression of E-selectin by surrounding follicular dendritic cells [13].
  • Te administration by either parenteral injection or implantation caused significant regression of established thyroiditis [14].
  • Lymphocytic thyroiditis was not accompanied by any consistent changes in serum T4, T3, and TSH concentrations or in the serum TSH response to thyrotropin-releasing hormone (TRH) suggesting that the thyroiditis was not of sufficient severity or duration to induce primary thyroid gland failure [15].
  • This report describes the development of triiodothyronine (T3) antibodies in a patient with Hashimoto's thyroiditis that resulted in compensated hypothyroidism and hyperprolactinemia [16].

Biological context of Thyroiditis

  • T-cell receptor (TcR) beta and gamma gene loci were studied in T cells derived from the thyroid glands of a patient with Hashimoto's (HT) and another with Graves' (GD) autoimmune thyroiditis. These analyzes shown that the T-cell response in autoimmune thyroiditis is multiclonal [18]

Anatomical context of Thyroiditis


Gene context of Thyroiditis


Analytical, diagnostic and therapeutic context of Thyroiditis


  1. Canine thyroid neoplasms: epidemiologic features. Hayes, H.M., Fraumeni, J.F. J. Natl. Cancer Inst. (1975) [Pubmed]
  2. Anti-asialo-GM1 antibody in sera from patients with Graves' disease and Hashimoto's thyroiditis. Sawada, K., Sakurami, T., Imura, H., Iwamori, M., Nabai, Y. Lancet (1980) [Pubmed]
  3. Amiodarone-associated thyrotoxicosis masquerading as painful thyroiditis. Miaskiewicz, S.L., Amico, J.A., Follansbee, W.P., Levey, G.S. Ann. Intern. Med. (1987) [Pubmed]
  4. Environmental iodine intake and thyroid dysfunction during chronic amiodarone therapy. Martino, E., Safran, M., Aghini-Lombardi, F., Rajatanavin, R., Lenziardi, M., Fay, M., Pacchiarotti, A., Aronin, N., Macchia, E., Haffajee, C. Ann. Intern. Med. (1984) [Pubmed]
  5. Human monoclonal multiple-organ-reactive autoantibodies distinguished by mouse monoclonal anti-idiotypic antibodies: expression of idiotopes in humans with and without autoimmune diseases. Uchigata, Y., Prabhakar, B.S., Salata, K.F., Ginsberg-Fellner, F., Notkins, A.L. J. Immunol. (1987) [Pubmed]
  6. Steroid-responsive encephalopathy associated with Hashimoto's thyroiditis in an adolescent with chronic hallucinations and depression: case report and review. Mahmud, F.H., Lteif, A.N., Renaud, D.L., Reed, A.M., Brands, C.K. Pediatrics (2003) [Pubmed]
  7. Thyroiditis and hepatitis: Fas on the road to disease. French, L.E., Tschopp, J. Nat. Med. (1997) [Pubmed]
  8. The effects of amiodarone on the thyroid. Martino, E., Bartalena, L., Bogazzi, F., Braverman, L.E. Endocr. Rev. (2001) [Pubmed]
  9. Potential involvement of Fas and its ligand in the pathogenesis of Hashimoto's thyroiditis. Giordano, C., Stassi, G., De Maria, R., Todaro, M., Richiusa, P., Papoff, G., Ruberti, G., Bagnasco, M., Testi, R., Galluzzo, A. Science (1997) [Pubmed]
  10. Control of target cell survival in thyroid autoimmunity by T helper cytokines via regulation of apoptotic proteins. Stassi, G., Di Liberto, D., Todaro, M., Zeuner, A., Ricci-Vitiani, L., Stoppacciaro, A., Ruco, L., Farina, F., Zummo, G., De Maria, R. Nat. Immunol. (2000) [Pubmed]
  11. Bone mineral density in premenopausal women receiving long-term physiological doses of levothyroxine. Kung, A.W., Pun, K.K. JAMA (1991) [Pubmed]
  12. Influence of methimazole on murine thyroiditis. Evidence for immunosuppression in vivo. Davies, T.F., Weiss, I., Gerber, M.A. J. Clin. Invest. (1984) [Pubmed]
  13. B lymphocyte binding to E- and P-selectins is mediated through the de novo expression of carbohydrates on in vitro and in vivo activated human B cells. Postigo, A.A., Marazuela, M., Sánchez-Madrid, F., de Landázuri, M.O. J. Clin. Invest. (1994) [Pubmed]
  14. Beneficial effect of testosterone in the treatment of chronic autoimmune thyroiditis in rats. Ansar Ahmed, S., Young, P.R., Penhale, W.J. J. Immunol. (1986) [Pubmed]
  15. Lymphocytic thyroiditis and diabetes in the BB/W rat. A new model of autoimmune endocrinopathy. Sternthal, E., Like, A.A., Sarantis, K., Braverman, L.E. Diabetes (1981) [Pubmed]
  16. Hypothyroidism, triiodothyronine antibodies, and hyperprolactinemia. Henry, R.R., Reyes, F.I., Faiman, C. Arch. Intern. Med. (1981) [Pubmed]
  17. Autoimmunity to human thyroglobulin. Respective epitopic specificity patterns of anti-human thyroglobulin autoantibodies in patients with Sjögren's syndrome and patients with Hashimoto's thyroiditis. Bouanani, M., Bataille, R., Piechaczyk, M., Salhi, S.L., Pau, B., Bastide, M. Arthritis Rheum. (1991) [Pubmed]
  18. Analysis of T-cell receptor usage in activated T-cell clones from Hashimoto's thyroiditis and Graves' disease. Lipoldova, M., Londei, M., Grubeck-Loebenstein, B., Feldmann, M., Owen, M.J. J. Autoimmun. (1989) [Pubmed]
  19. Thyroid-specific expression of IFN-gamma limits experimental autoimmune thyroiditis by suppressing lymphocyte activation in cervical lymph nodes. Barin, J.G., Afanasyeva, M., Talor, M.V., Rose, N.R., Burek, C.L., Caturegli, P. J. Immunol. (2003) [Pubmed]
  20. Localization of quantitative trait loci regulating adjuvant-induced arthritis in rats: evidence for genetic factors common to multiple autoimmune diseases. Kawahito, Y., Cannon, G.W., Gulko, P.S., Remmers, E.F., Longman, R.E., Reese, V.R., Wang, J., Griffiths, M.M., Wilder, R.L. J. Immunol. (1998) [Pubmed]
  21. Postpartum thyroiditis in women with hypothyroidism antedating pregnancy? Caixàs, A., Albareda, M., García-Patterson, A., Rodríguez-Espinosa, J., de Leiva, A., Corcoy, R. J. Clin. Endocrinol. Metab. (1999) [Pubmed]
  22. Antithyroid microsomal autoantibodies and HLA-DR5 are associated with postpartum thyroid dysfunction: evidence supporting an autoimmune pathogenesis. Vargas, M.T., Briones-Urbina, R., Gladman, D., Papsin, F.R., Walfish, P.G. J. Clin. Endocrinol. Metab. (1988) [Pubmed]
  23. An immunotoxin of ricin A chain conjugated to thyroglobulin selectively suppresses the antithyroglobulin autoantibody response. Rennie, D.P., McGregor, A.M., Wright, J., Weetman, A.P., Hall, R., Thorpe, P. Lancet (1983) [Pubmed]
  24. Selective induction of dendritic cells using granulocyte macrophage-colony stimulating factor, but not fms-like tyrosine kinase receptor 3-ligand, activates thyroglobulin-specific CD4+/CD25+ T cells and suppresses experimental autoimmune thyroiditis. Vasu, C., Dogan, R.N., Holterman, M.J., Prabhakar, B.S. J. Immunol. (2003) [Pubmed]
  25. H2A- and H2E-derived CD4+CD25+ regulatory T cells: a potential role in reciprocal inhibition by class II genes in autoimmune thyroiditis. Morris, G.P., Yan, Y., David, C.S., Kong, Y.C. J. Immunol. (2005) [Pubmed]
  26. Cloning and analysis of IgG kappa and IgG lambda anti-thyroglobulin autoantibodies from a patient with Hashimoto's thyroiditis: evidence for in vivo antigen-driven repertoire selection. McIntosh, R.S., Asghar, M.S., Watson, P.F., Kemp, E.H., Weetman, A.P. J. Immunol. (1996) [Pubmed]
  27. Clinical significance of antibodies to native or denatured 60-kd or 52-kd Ro/SS-A proteins in Sjögren's syndrome. Tsuzaka, K., Fujii, T., Akizuki, M., Mimori, T., Tojo, T., Fujii, H., Tsukatani, Y., Kubo, A., Homma, M. Arthritis Rheum. (1994) [Pubmed]
  28. Regulation of signal transducer and activator of transcription 1 (STAT1) and STAT1-dependent genes by RET/PTC (rearranged in transformation/papillary thyroid carcinoma) oncogenic tyrosine kinases. Hwang, E.S., Kim, D.W., Hwang, J.H., Jung, H.S., Suh, J.M., Park, Y.J., Chung, H.K., Song, J.H., Park, K.C., Park, S.H., Yun, H.J., Kim, J.M., Shong, M. Mol. Endocrinol. (2004) [Pubmed]
  29. Thyrocytes express a functional toll-like receptor 3: overexpression can be induced by viral infection and reversed by phenylmethimazole and is associated with Hashimoto's autoimmune thyroiditis. Harii, N., Lewis, C.J., Vasko, V., McCall, K., Benavides-Peralta, U., Sun, X., Ringel, M.D., Saji, M., Giuliani, C., Napolitano, G., Goetz, D.J., Kohn, L.D. Mol. Endocrinol. (2005) [Pubmed]
  30. Thyrotropin-receptor and thyroid peroxidase-specific T cell clones and their cytokine profile in autoimmune thyroid disease. Fisfalen, M.E., Palmer, E.M., Van Seventer, G.A., Soltani, K., Sawai, Y., Kaplan, E., Hidaka, Y., Ober, C., DeGroot, L.J. J. Clin. Endocrinol. Metab. (1997) [Pubmed]
  31. Codon 17 polymorphism of the cytotoxic T lymphocyte antigen 4 gene in Hashimoto's thyroiditis and Addison's disease. Donner, H., Braun, J., Seidl, C., Rau, H., Finke, R., Ventz, M., Walfish, P.G., Usadel, K.H., Badenhoop, K. J. Clin. Endocrinol. Metab. (1997) [Pubmed]
  32. Susceptibility and resistance alleles of human leukocyte antigen (HLA) DQA1 and HLA DQB1 are shared in endocrine autoimmune disease. Badenhoop, K., Walfish, P.G., Rau, H., Fischer, S., Nicolay, A., Bogner, U., Schleusener, H., Usadel, K.H. J. Clin. Endocrinol. Metab. (1995) [Pubmed]
  33. Islet cell antibodies in the Japanese population and subjects with type 1 (insulin-dependent) diabetes. Notsu, K., Oka, N., Note, S., Nabeya, N., Kuno, S., Sakurami, T. Diabetologia (1985) [Pubmed]
  34. Immunopathological studies on thyroid immunity. IX. Thyroid and renal amyloidosis in thyroglobulin immunized rabbits. Blumenthal, H.T., Premachandra, B.N. J. Pathol. (1987) [Pubmed]
  35. Thyroid-stimulating immunoglobulins in Hashimoto's thyroiditis measured by radioreceptor assay and adenylate cyclase stimulation and their relationship to HLA-D alleles. Bliddal, H., Bech, K., Feldt-Rasmussen, U., Thomsen, M., Ryder, L.P., Hansen, J.M., Siersbaek-Nielsen, K., Friis, T. J. Clin. Endocrinol. Metab. (1982) [Pubmed]
  36. Thyroid peroxidase autoantibody fingerprints. II. A longitudinal study in postpartum thyroiditis. Jaume, J.C., Parkes, A.B., Lazarus, J.H., Hall, R., Costante, G., McLachlan, S.M., Rapoport, B. J. Clin. Endocrinol. Metab. (1995) [Pubmed]
WikiGenes - Universities