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MeSH Review

Thyroiditis

 
 
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Disease relevance of Thyroiditis

 

Psychiatry related information on Thyroiditis

 

High impact information on Thyroiditis

  • Thyroiditis and hepatitis: Fas on the road to disease [7].
  • AIT is primarily related to excess iodine-induced thyroid hormone synthesis in an abnormal thyroid gland (type I AIT) or to amiodarone-related destructive thyroiditis (type II AIT), but mixed forms frequently exist [8].
  • The mechanisms responsible for thyrocyte destruction in Hashimoto's thyroiditis (HT) are poorly understood [9].
  • After autoimmune inflammation, interactions between CD95 and its ligand (CD95L) mediate thyrocyte destruction in Hashimoto's thyroiditis (HT) [10].
  • Total body and regional bone mineral density (BMD) levels were determined in 26 premenopausal women with Hashimoto's thyroiditis receiving long-term physiological doses of levothyroxine sodium replacement therapy [11].
 

Chemical compound and disease context of Thyroiditis

  • Histological examination revealed a marked thyroiditis in hTg-only animals and a significantly reduced degree of mononuclear cell infiltration and follicular destruction in the M plus T4-treated groups (graded 1.9 compared with 3.6 in hTg-only P = less than 0.01) [12].
  • B cells infiltrating inflamed tissues like in Hashimoto's thyroiditis, also expressed these selectin-binding carbohydrates in parallel with the expression of E-selectin by surrounding follicular dendritic cells [13].
  • Te administration by either parenteral injection or implantation caused significant regression of established thyroiditis [14].
  • Lymphocytic thyroiditis was not accompanied by any consistent changes in serum T4, T3, and TSH concentrations or in the serum TSH response to thyrotropin-releasing hormone (TRH) suggesting that the thyroiditis was not of sufficient severity or duration to induce primary thyroid gland failure [15].
  • This report describes the development of triiodothyronine (T3) antibodies in a patient with Hashimoto's thyroiditis that resulted in compensated hypothyroidism and hyperprolactinemia [16].
 

Biological context of Thyroiditis

  • T-cell receptor (TcR) beta and gamma gene loci were studied in T cells derived from the thyroid glands of a patient with Hashimoto's (HT) and another with Graves' (GD) autoimmune thyroiditis. These analyzes shown that the T-cell response in autoimmune thyroiditis is multiclonal [18]
 

Anatomical context of Thyroiditis

 

Gene context of Thyroiditis

 

Analytical, diagnostic and therapeutic context of Thyroiditis

References

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  2. Anti-asialo-GM1 antibody in sera from patients with Graves' disease and Hashimoto's thyroiditis. Sawada, K., Sakurami, T., Imura, H., Iwamori, M., Nabai, Y. Lancet (1980) [Pubmed]
  3. Amiodarone-associated thyrotoxicosis masquerading as painful thyroiditis. Miaskiewicz, S.L., Amico, J.A., Follansbee, W.P., Levey, G.S. Ann. Intern. Med. (1987) [Pubmed]
  4. Environmental iodine intake and thyroid dysfunction during chronic amiodarone therapy. Martino, E., Safran, M., Aghini-Lombardi, F., Rajatanavin, R., Lenziardi, M., Fay, M., Pacchiarotti, A., Aronin, N., Macchia, E., Haffajee, C. Ann. Intern. Med. (1984) [Pubmed]
  5. Human monoclonal multiple-organ-reactive autoantibodies distinguished by mouse monoclonal anti-idiotypic antibodies: expression of idiotopes in humans with and without autoimmune diseases. Uchigata, Y., Prabhakar, B.S., Salata, K.F., Ginsberg-Fellner, F., Notkins, A.L. J. Immunol. (1987) [Pubmed]
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  14. Beneficial effect of testosterone in the treatment of chronic autoimmune thyroiditis in rats. Ansar Ahmed, S., Young, P.R., Penhale, W.J. J. Immunol. (1986) [Pubmed]
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  18. Analysis of T-cell receptor usage in activated T-cell clones from Hashimoto's thyroiditis and Graves' disease. Lipoldova, M., Londei, M., Grubeck-Loebenstein, B., Feldmann, M., Owen, M.J. J. Autoimmun. (1989) [Pubmed]
  19. Thyroid-specific expression of IFN-gamma limits experimental autoimmune thyroiditis by suppressing lymphocyte activation in cervical lymph nodes. Barin, J.G., Afanasyeva, M., Talor, M.V., Rose, N.R., Burek, C.L., Caturegli, P. J. Immunol. (2003) [Pubmed]
  20. Localization of quantitative trait loci regulating adjuvant-induced arthritis in rats: evidence for genetic factors common to multiple autoimmune diseases. Kawahito, Y., Cannon, G.W., Gulko, P.S., Remmers, E.F., Longman, R.E., Reese, V.R., Wang, J., Griffiths, M.M., Wilder, R.L. J. Immunol. (1998) [Pubmed]
  21. Postpartum thyroiditis in women with hypothyroidism antedating pregnancy? Caixàs, A., Albareda, M., García-Patterson, A., Rodríguez-Espinosa, J., de Leiva, A., Corcoy, R. J. Clin. Endocrinol. Metab. (1999) [Pubmed]
  22. Antithyroid microsomal autoantibodies and HLA-DR5 are associated with postpartum thyroid dysfunction: evidence supporting an autoimmune pathogenesis. Vargas, M.T., Briones-Urbina, R., Gladman, D., Papsin, F.R., Walfish, P.G. J. Clin. Endocrinol. Metab. (1988) [Pubmed]
  23. An immunotoxin of ricin A chain conjugated to thyroglobulin selectively suppresses the antithyroglobulin autoantibody response. Rennie, D.P., McGregor, A.M., Wright, J., Weetman, A.P., Hall, R., Thorpe, P. Lancet (1983) [Pubmed]
  24. Selective induction of dendritic cells using granulocyte macrophage-colony stimulating factor, but not fms-like tyrosine kinase receptor 3-ligand, activates thyroglobulin-specific CD4+/CD25+ T cells and suppresses experimental autoimmune thyroiditis. Vasu, C., Dogan, R.N., Holterman, M.J., Prabhakar, B.S. J. Immunol. (2003) [Pubmed]
  25. H2A- and H2E-derived CD4+CD25+ regulatory T cells: a potential role in reciprocal inhibition by class II genes in autoimmune thyroiditis. Morris, G.P., Yan, Y., David, C.S., Kong, Y.C. J. Immunol. (2005) [Pubmed]
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  27. Clinical significance of antibodies to native or denatured 60-kd or 52-kd Ro/SS-A proteins in Sjögren's syndrome. Tsuzaka, K., Fujii, T., Akizuki, M., Mimori, T., Tojo, T., Fujii, H., Tsukatani, Y., Kubo, A., Homma, M. Arthritis Rheum. (1994) [Pubmed]
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