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Gene Review:

unc-4 - CG6269 gene product from transcript CG6269-RC

Drosophila melanogaster

Synonyms: CG6269, DPHD-1, Dmel\CG6269, Dunc-4, Homeobox protein unc-4, ...

Tabuchi, K. et al., Wen, S.Y. et al., Ting, C.T. et al.

Ting, Tsaur, Sun, Browne, Chen, Patel, Wu, Wen, Shimada, Kawai, Toda,

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Disease relevance of unc-4

The Odysseus (OdsH) gene was duplicated from its ancestral neuron-expressed gene, unc-4, and then evolved very rapidly under strong positive Darwinian selection as a speciation gene causing hybrid-male sterility between closely related species of the Drosophila simulans clade [1].

High impact information on unc-4

OdsH has evolved at a very high rate, whereas its most immediate paralog, unc-4, is nearly identical among species in the Drosophila melanogaster subgroup [2].
We have isolated a novel Drosophila paired-like homeobox gene, DPHD-1 [3].
Whole-mount in situ hybridization of embryos and third-instar larvae revealed that the DPHD-1 mRNA is specifically localized in subsets of postmitotic neurons in the central nervous system (CNS) and in the developing epidermis with a segmentally repeated pattern [3].

References

Strong purifying selection on the Odysseus gene in two clades of sibling species of the Drosophila montium species subgroup. Wen, S.Y., Shimada, K., Kawai, K., Toda, M.J. J. Mol. Evol. (2006) [Pubmed]
Gene duplication and speciation in Drosophila: evidence from the Odysseus locus. Ting, C.T., Tsaur, S.C., Sun, S., Browne, W.E., Chen, Y.C., Patel, N.H., Wu, C.I. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
A novel Drosophila paired-like homeobox gene related to Caenorhabditis elegans unc-4 is expressed in subsets of postmitotic neurons and epidermal cells. Tabuchi, K., Yoshikawa, S., Yuasa, Y., Sawamoto, K., Okano, H. Neurosci. Lett. (1998) [Pubmed]

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