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Gene Review:

OdsH - Ods-site homeobox

Drosophila melanogaster

Synonyms: CG6352, Dmel\CG6352, OdsH[mel], odsH, odsh

Sun, S. et al., Ting, C.T. et al., Ting, C.T. et al.

Ting, Tsaur, Sun, Browne, Chen, Patel, Wu,

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Disease relevance of OdsH

Here, we show that a hybrid-male sterility gene, Odysseus (OdsH), arose by gene duplication in the Drosophila genome [1].
The implication of a weak effect of OdsH on the normal phenotype but a strong influence on hybrid male sterility is discussed in light of Haldane's rule of postmating isolation [2].

High impact information on OdsH

OdsH has evolved at a very high rate, whereas its most immediate paralog, unc-4, is nearly identical among species in the Drosophila melanogaster subgroup [1].
In this study, we analyzed DNA polymorphism at the Odysseus (OdsH) locus of hybrid sterility between Drosophila mauritiana and Drosophila simulans and were able to verify such a prediction [3].
To understand how postmating isolation is connected to the normal process of species divergence and why hybrid male sterility is often the first sign of speciation, we analyzed the Odysseus (OdsH) gene of hybrid male sterility in Drosophila [2].

References

Gene duplication and speciation in Drosophila: evidence from the Odysseus locus. Ting, C.T., Tsaur, S.C., Sun, S., Browne, W.E., Chen, Y.C., Patel, N.H., Wu, C.I. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
The normal function of a speciation gene, Odysseus, and its hybrid sterility effect. Sun, S., Ting, C.T., Wu, C.I. Science (2004) [Pubmed]
The phylogeny of closely related species as revealed by the genealogy of a speciation gene, Odysseus. Ting, C.T., Tsaur, S.C., Wu, C.I. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]

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