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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Infertility


Psychiatry related information on Infertility


High impact information on Infertility


Chemical compound and disease context of Infertility


Biological context of Infertility


Anatomical context of Infertility

  • Accepting the concept that POF is a heterogenous disorder in which some of the idiopathic forms are based on an abnormal self-recognition by the immune system will lead to new approaches in the treatment of infertility of these patients [26].
  • BACKGROUND: We investigated the incidence of invasive cancer of the breast, ovary, and uterus in a cohort of patients who had undergone in-vitro-fertilisation (IVF) treatment and examined whether cause of infertility or exposure to fertility drugs to induce superovulation was associated with an increased cancer risk [27].
  • Steel(17H) (Sl(17H)) is an SCF mutant that demonstrates melanocyte defects and sterility in males but not in females [28].
  • Therefore, the infertility of PEA3 mutant males involves either mechanisms proximal to the cavernosal smooth muscle or an ejaculatory dysfunction [29].
  • Mice with W mutations characterized by hypopigmentation, sterility, anemia, and mast cell deficiency have abnormalities in c-kit, a receptor with tyrosine kinase activity [30].

Gene context of Infertility

  • FUS3 has a positive role in conjugation, because overexpression of FUS3 increases the pheromone sensitivity of wild-type cells, while the absence of FUS3 causes sterility [31].
  • Sexually dimorphic sterility phenotypes in Hoxa10-deficient mice [32].
  • Among the most interesting Sl mutations available for study are those that induce sterility in only one sex [33].
  • Disruption of mouse Spo11 results in infertility [34].
  • In summary, we show that brain-specific leptin signaling is sufficient to reverse the obesity, diabetes, and infertility of db/db mice [35].

Analytical, diagnostic and therapeutic context of Infertility


  1. Appendectomy and the risk of tubal infertility. Mueller, B.A., Daling, J.R., Moore, D.E., Weiss, N.S., Spadoni, L.R., Stadel, B.V., Soules, M.R. N. Engl. J. Med. (1986) [Pubmed]
  2. Partial rescue of the prophase I defects of Atm-deficient mice by p53 and p21 null alleles. Barlow, C., Liyanage, M., Moens, P.B., Deng, C.X., Ried, T., Wynshaw-Boris, A. Nat. Genet. (1997) [Pubmed]
  3. A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction. Clément, K., Vaisse, C., Lahlou, N., Cabrol, S., Pelloux, V., Cassuto, D., Gourmelen, M., Dina, C., Chambaz, J., Lacorte, J.M., Basdevant, A., Bougnères, P., Lebouc, Y., Froguel, P., Guy-Grand, B. Nature (1998) [Pubmed]
  4. A host parasite interaction rescues Drosophila oogenesis defects. Starr, D.J., Cline, T.W. Nature (2002) [Pubmed]
  5. Incident Chlamydia trachomatis infections among inner-city adolescent females. Burstein, G.R., Gaydos, C.A., Diener-West, M., Howell, M.R., Zenilman, J.M., Quinn, T.C. JAMA (1998) [Pubmed]
  6. Stem cell factor receptor (c-KIT) codon 816 mutations predict development of bilateral testicular germ-cell tumors. Looijenga, L.H., de Leeuw, H., van Oorschot, M., van Gurp, R.J., Stoop, H., Gillis, A.J., de Gouveia Brazao, C.A., Weber, R.F., Kirkels, W.J., van Dijk, T., von Lindern, M., Valk, P., Lajos, G., Olah, E., Nesland, J.M., Fosså, S.D., Oosterhuis, J.W. Cancer Res. (2003) [Pubmed]
  7. Microencapsulation of Leydig cells: a system for testosterone supplementation. Machluf, M., Orsola, A., Boorjian, S., Kershen, R., Atala, A. Endocrinology (2003) [Pubmed]
  8. Late luteal phase dydrogesterone in combination with clomiphene or tamoxifen in the treatment of infertility associated with irregular and infrequent menstruation: enhancing patient compliance. Viniker, D.A. Hum. Reprod. (1996) [Pubmed]
  9. The use of drugs in mothers of offspring with neural-tube defects. Medveczky, E., Puhó, E., Czeizel, E.A. Pharmacoepidemiology and drug safety. (2004) [Pubmed]
  10. Polycystic ovary syndrome and insulin resistance: thrifty genes struggling with over-feeding and sedentary life style? Holte, J. J. Endocrinol. Invest. (1998) [Pubmed]
  11. Silencing of unsynapsed meiotic chromosomes in the mouse. Turner, J.M., Mahadevaiah, S.K., Fernandez-Capetillo, O., Nussenzweig, A., Xu, X., Deng, C.X., Burgoyne, P.S. Nat. Genet. (2005) [Pubmed]
  12. Haploinsufficiency of protamine-1 or -2 causes infertility in mice. Cho, C., Willis, W.D., Goulding, E.H., Jung-Ha, H., Choi, Y.C., Hecht, N.B., Eddy, E.M. Nat. Genet. (2001) [Pubmed]
  13. Use of copper intrauterine devices and the risk of tubal infertility among nulligravid women. Hubacher, D., Lara-Ricalde, R., Taylor, D.J., Guerra-Infante, F., Guzmán-Rodríguez, R. N. Engl. J. Med. (2001) [Pubmed]
  14. Inactivation of Hdh in the brain and testis results in progressive neurodegeneration and sterility in mice. Dragatsis, I., Levine, M.S., Zeitlin, S. Nat. Genet. (2000) [Pubmed]
  15. Mice deficient of Lats1 develop soft-tissue sarcomas, ovarian tumours and pituitary dysfunction. St John, M.A., Tao, W., Fei, X., Fukumoto, R., Carcangiu, M.L., Brownstein, D.G., Parlow, A.F., McGrath, J., Xu, T. Nat. Genet. (1999) [Pubmed]
  16. Chromosome analysis of human oocytes recovered from preovulatory follicles in stimulated cycles. Wramsby, H., Fredga, K., Liedholm, P. N. Engl. J. Med. (1987) [Pubmed]
  17. Primary amenorrhoea and infertility due to a mutation in the beta-subunit of follicle-stimulating hormone. Matthews, C.H., Borgato, S., Beck-Peccoz, P., Adams, M., Tone, Y., Gambino, G., Casagrande, S., Tedeschini, G., Benedetti, A., Chatterjee, V.K. Nat. Genet. (1993) [Pubmed]
  18. Androgen insensitivity as a cause of infertility in otherwise normal men. Aiman, J., Griffin, J.E., Gazak, J.M., Wilson, J.D., MacDonald, P.C. N. Engl. J. Med. (1979) [Pubmed]
  19. Fertility in men exposed prenatally to diethylstilbestrol. Wilcox, A.J., Baird, D.D., Weinberg, C.R., Hornsby, P.P., Herbst, A.L. N. Engl. J. Med. (1995) [Pubmed]
  20. Efficacy of superovulation and intrauterine insemination in the treatment of infertility. National Cooperative Reproductive Medicine Network. Guzick, D.S., Carson, S.A., Coutifaris, C., Overstreet, J.W., Factor-Litvak, P., Steinkampf, M.P., Hill, J.A., Mastroianni, L., Buster, J.E., Nakajima, S.T., Vogel, D.L., Canfield, R.E. N. Engl. J. Med. (1999) [Pubmed]
  21. Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin. Chehab, F.F., Lim, M.E., Lu, R. Nat. Genet. (1996) [Pubmed]
  22. Commuting the death sentence: how oocytes strive to survive. Tilly, J.L. Nat. Rev. Mol. Cell Biol. (2001) [Pubmed]
  23. Follicle-stimulating hormone is secreted more irregularly than luteinizing hormone in both humans and sheep. Pincus, S.M., Padmanabhan, V., Lemon, W., Randolph, J., Rees Midgley, A. J. Clin. Invest. (1998) [Pubmed]
  24. MUC 1: a genetic susceptibility to infertility? Horne, A.W., White, J.O., Margara, R.A., Williams, R., Winston, R.M., Lalani, E. Lancet (2001) [Pubmed]
  25. An early and massive wave of germinal cell apoptosis is required for the development of functional spermatogenesis. Rodriguez, I., Ody, C., Araki, K., Garcia, I., Vassalli, P. EMBO J. (1997) [Pubmed]
  26. Premature ovarian failure and ovarian autoimmunity. Hoek, A., Schoemaker, J., Drexhage, H.A. Endocr. Rev. (1997) [Pubmed]
  27. Risk of cancer after use of fertility drugs with in-vitro fertilisation. Venn, A., Watson, L., Bruinsma, F., Giles, G., Healy, D. Lancet (1999) [Pubmed]
  28. The presence of novel amino acids in the cytoplasmic domain of stem cell factor results in hematopoietic defects in Steel(17H) mice. Kapur, R., Cooper, R., Xiao, X., Weiss, M.J., Donovan, P., Williams, D.A. Blood (1999) [Pubmed]
  29. Male sexual dysfunction in mice bearing targeted mutant alleles of the PEA3 ets gene. Laing, M.A., Coonrod, S., Hinton, B.T., Downie, J.W., Tozer, R., Rudnicki, M.A., Hassell, J.A. Mol. Cell. Biol. (2000) [Pubmed]
  30. Enhancement of murine blast cell colony formation in culture by recombinant rat stem cell factor, ligand for c-kit. Tsuji, K., Zsebo, K.M., Ogawa, M. Blood (1991) [Pubmed]
  31. FUS3 encodes a cdc2+/CDC28-related kinase required for the transition from mitosis into conjugation. Elion, E.A., Grisafi, P.L., Fink, G.R. Cell (1990) [Pubmed]
  32. Sexually dimorphic sterility phenotypes in Hoxa10-deficient mice. Satokata, I., Benson, G., Maas, R. Nature (1995) [Pubmed]
  33. Developmental abnormalities in Steel17H mice result from a splicing defect in the steel factor cytoplasmic tail. Brannan, C.I., Bedell, M.A., Resnick, J.L., Eppig, J.J., Handel, M.A., Williams, D.E., Lyman, S.D., Donovan, P.J., Jenkins, N.A., Copeland, N.G. Genes Dev. (1992) [Pubmed]
  34. The mouse Spo11 gene is required for meiotic chromosome synapsis. Romanienko, P.J., Camerini-Otero, R.D. Mol. Cell (2000) [Pubmed]
  35. Complete rescue of obesity, diabetes, and infertility in db/db mice by neuron-specific LEPR-B transgenes. de Luca, C., Kowalski, T.J., Zhang, Y., Elmquist, J.K., Lee, C., Kilimann, M.W., Ludwig, T., Liu, S.M., Chua, S.C. J. Clin. Invest. (2005) [Pubmed]
  36. Primary tubal infertility in relation to the use of an intrauterine device. Daling, J.R., Weiss, N.S., Metch, B.J., Chow, W.H., Soderstrom, R.M., Moore, D.E., Spadoni, L.R., Stadel, B.V. N. Engl. J. Med. (1985) [Pubmed]
  37. Proportion of cystic fibrosis gene mutations not detected by routine testing in men with obstructive azoospermia. Mak, V., Zielenski, J., Tsui, L.C., Durie, P., Zini, A., Martin, S., Longley, T.B., Jarvi, K.A. JAMA (1999) [Pubmed]
  38. The relationship of tubal infertility to barrier method and oral contraceptive use. Cramer, D.W., Goldman, M.B., Schiff, I., Belisle, S., Albrecht, B., Stadel, B., Gibson, M., Wilson, E., Stillman, R., Thompson, I. JAMA (1987) [Pubmed]
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