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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
MeSH Review

Infertility

 
 
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Disease relevance of Infertility

 

Psychiatry related information on Infertility

 

High impact information on Infertility

 

Chemical compound and disease context of Infertility

 

Biological context of Infertility

 

Anatomical context of Infertility

  • Accepting the concept that POF is a heterogenous disorder in which some of the idiopathic forms are based on an abnormal self-recognition by the immune system will lead to new approaches in the treatment of infertility of these patients [26].
  • BACKGROUND: We investigated the incidence of invasive cancer of the breast, ovary, and uterus in a cohort of patients who had undergone in-vitro-fertilisation (IVF) treatment and examined whether cause of infertility or exposure to fertility drugs to induce superovulation was associated with an increased cancer risk [27].
  • Steel(17H) (Sl(17H)) is an SCF mutant that demonstrates melanocyte defects and sterility in males but not in females [28].
  • Therefore, the infertility of PEA3 mutant males involves either mechanisms proximal to the cavernosal smooth muscle or an ejaculatory dysfunction [29].
  • Mice with W mutations characterized by hypopigmentation, sterility, anemia, and mast cell deficiency have abnormalities in c-kit, a receptor with tyrosine kinase activity [30].
 

Gene context of Infertility

  • FUS3 has a positive role in conjugation, because overexpression of FUS3 increases the pheromone sensitivity of wild-type cells, while the absence of FUS3 causes sterility [31].
  • Sexually dimorphic sterility phenotypes in Hoxa10-deficient mice [32].
  • Among the most interesting Sl mutations available for study are those that induce sterility in only one sex [33].
  • Disruption of mouse Spo11 results in infertility [34].
  • In summary, we show that brain-specific leptin signaling is sufficient to reverse the obesity, diabetes, and infertility of db/db mice [35].
 

Analytical, diagnostic and therapeutic context of Infertility

References

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  15. Mice deficient of Lats1 develop soft-tissue sarcomas, ovarian tumours and pituitary dysfunction. St John, M.A., Tao, W., Fei, X., Fukumoto, R., Carcangiu, M.L., Brownstein, D.G., Parlow, A.F., McGrath, J., Xu, T. Nat. Genet. (1999) [Pubmed]
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  23. Follicle-stimulating hormone is secreted more irregularly than luteinizing hormone in both humans and sheep. Pincus, S.M., Padmanabhan, V., Lemon, W., Randolph, J., Rees Midgley, A. J. Clin. Invest. (1998) [Pubmed]
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  27. Risk of cancer after use of fertility drugs with in-vitro fertilisation. Venn, A., Watson, L., Bruinsma, F., Giles, G., Healy, D. Lancet (1999) [Pubmed]
  28. The presence of novel amino acids in the cytoplasmic domain of stem cell factor results in hematopoietic defects in Steel(17H) mice. Kapur, R., Cooper, R., Xiao, X., Weiss, M.J., Donovan, P., Williams, D.A. Blood (1999) [Pubmed]
  29. Male sexual dysfunction in mice bearing targeted mutant alleles of the PEA3 ets gene. Laing, M.A., Coonrod, S., Hinton, B.T., Downie, J.W., Tozer, R., Rudnicki, M.A., Hassell, J.A. Mol. Cell. Biol. (2000) [Pubmed]
  30. Enhancement of murine blast cell colony formation in culture by recombinant rat stem cell factor, ligand for c-kit. Tsuji, K., Zsebo, K.M., Ogawa, M. Blood (1991) [Pubmed]
  31. FUS3 encodes a cdc2+/CDC28-related kinase required for the transition from mitosis into conjugation. Elion, E.A., Grisafi, P.L., Fink, G.R. Cell (1990) [Pubmed]
  32. Sexually dimorphic sterility phenotypes in Hoxa10-deficient mice. Satokata, I., Benson, G., Maas, R. Nature (1995) [Pubmed]
  33. Developmental abnormalities in Steel17H mice result from a splicing defect in the steel factor cytoplasmic tail. Brannan, C.I., Bedell, M.A., Resnick, J.L., Eppig, J.J., Handel, M.A., Williams, D.E., Lyman, S.D., Donovan, P.J., Jenkins, N.A., Copeland, N.G. Genes Dev. (1992) [Pubmed]
  34. The mouse Spo11 gene is required for meiotic chromosome synapsis. Romanienko, P.J., Camerini-Otero, R.D. Mol. Cell (2000) [Pubmed]
  35. Complete rescue of obesity, diabetes, and infertility in db/db mice by neuron-specific LEPR-B transgenes. de Luca, C., Kowalski, T.J., Zhang, Y., Elmquist, J.K., Lee, C., Kilimann, M.W., Ludwig, T., Liu, S.M., Chua, S.C. J. Clin. Invest. (2005) [Pubmed]
  36. Primary tubal infertility in relation to the use of an intrauterine device. Daling, J.R., Weiss, N.S., Metch, B.J., Chow, W.H., Soderstrom, R.M., Moore, D.E., Spadoni, L.R., Stadel, B.V. N. Engl. J. Med. (1985) [Pubmed]
  37. Proportion of cystic fibrosis gene mutations not detected by routine testing in men with obstructive azoospermia. Mak, V., Zielenski, J., Tsui, L.C., Durie, P., Zini, A., Martin, S., Longley, T.B., Jarvi, K.A. JAMA (1999) [Pubmed]
  38. The relationship of tubal infertility to barrier method and oral contraceptive use. Cramer, D.W., Goldman, M.B., Schiff, I., Belisle, S., Albrecht, B., Stadel, B., Gibson, M., Wilson, E., Stillman, R., Thompson, I. JAMA (1987) [Pubmed]
 
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