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Gene Review

SIRPA  -  signal-regulatory protein alpha

Bos taurus

Synonyms: MYD-1, PTPNS1
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High impact information on PTPNS1

  • Cloning of two members of the SIRP alpha family of protein tyrosine phosphatase binding proteins in cattle that are expressed on monocytes and a subpopulation of dendritic cells and which mediate binding to CD4 T cells [1].

Analytical, diagnostic and therapeutic context of PTPNS1

  • Phenotypic analysis of the transformed cells by immunostaining and flow cytometry revealed that they expressed MHC class I and II antigens, the myeloid marker MyD (SIRP alpha) and the bovine WC6 (workshop cluster 6) molecule [2].


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